4-(tert-butyl-dimethyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-octan-3-ol

Base Information

Chemical Name:4-(tert-butyl-dimethyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-octan-3-ol
CAS No.:929804-21-7
Molecular Formula:C₂₃H₄₂O₄Si
Molecular Weight:410.67
Hs Code.:

4-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-octan-3-ol

Synonyms:4-(tert-butyl-dimethyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-octan-3-ol

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Chemical Property of 4-(tert-butyl-dimethyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-octan-3-ol

Chemical Property:

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Technology Process of 4-(tert-butyl-dimethyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-octan-3-ol

There total 7 articles about 4-(tert-butyl-dimethyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-octan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929804-17-1
2-butyl-4-(4-methoxy-benzyloxy)-pent-2-en-1-ol

: 929804-21-7
4-(tert-butyl-dimethyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-octan-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / m-CPBA; NaHCO₃ / CH₂Cl₂ / 0.75 h / 0 °C

2: 90 percent / ZnCl₂; Zn / Cp₂TiCl₂ / tetrahydrofuran / 12 h / -20 - 20 °C

3: 80 percent / Na(CN)BH₃; TMSCl; 4 Angstroem molecular sieves / acetonitrile / 0.17 h / 0 °C

4: Et₃N / CH₂Cl₂ / 12 h / 0 - 20 °C

With chloro-trimethyl-silane; 4 A molecular sieve; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc(II) chloride; zinc; bis(cyclopentadienyl)titanium dichloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2006.12.088

Reference yield:

: 929804-18-2
{2-butyl-3-[1-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-methanol

: 929804-21-7
4-(tert-butyl-dimethyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-octan-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / ZnCl₂; Zn / Cp₂TiCl₂ / tetrahydrofuran / 12 h / -20 - 20 °C

2: 80 percent / Na(CN)BH₃; TMSCl; 4 Angstroem molecular sieves / acetonitrile / 0.17 h / 0 °C

3: Et₃N / CH₂Cl₂ / 12 h / 0 - 20 °C

With chloro-trimethyl-silane; 4 A molecular sieve; sodium cyanoborohydride; triethylamine; zinc(II) chloride; zinc; bis(cyclopentadienyl)titanium dichloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2006.12.088

Reference yield:

: 929804-16-0
2-butyl-4-(4-methoxy-benzyloxy)-pent-2-enoic acid ethyl ester

: 929804-21-7
4-(tert-butyl-dimethyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-octan-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: DIBAL-H / CH₂Cl₂ / 0.5 h / -78 - -10 °C

2: 72 percent / m-CPBA; NaHCO₃ / CH₂Cl₂ / 0.75 h / 0 °C

3: 90 percent / ZnCl₂; Zn / Cp₂TiCl₂ / tetrahydrofuran / 12 h / -20 - 20 °C

4: 80 percent / Na(CN)BH₃; TMSCl; 4 Angstroem molecular sieves / acetonitrile / 0.17 h / 0 °C

5: Et₃N / CH₂Cl₂ / 12 h / 0 - 20 °C

With chloro-trimethyl-silane; 4 A molecular sieve; diisobutylaluminium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc(II) chloride; zinc; bis(cyclopentadienyl)titanium dichloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2006.12.088