N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yI}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

Base Information

Chemical Name:N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yI}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide
CAS No.:1055925-77-3
Molecular Formula:C₂₈H₃₈N₁₀O
Molecular Weight:530.676
Hs Code.:

Synonyms:N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yI}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

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Chemical Property of N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yI}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

Chemical Property:

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Technology Process of N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yI}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

There total 15 articles about N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yI}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1055927-86-0
3-(4-methyl-1-piperazinyl) benzoyl chloride

: 1055926-88-9
6-(1-cyclopentylhydrazino)-9-[3-(dimethylamino)propyl]-9H-purine-2-carbonitrile trifluoroacetate

: 1055925-77-3
N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yI}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

Guidance literature:: With potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 928148-36-1
1,1-dimethylethyl-2-(cyclopentylmethyl)-hydrazine-carboxylate

: 1055925-77-3
N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yI}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

Guidance literature:: Multi-step reaction with 13 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 6 h / Heating / reflux

2: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 2 h / 150 °C

3: dowex 50x2-200 ion exchange resin / ethanol / 1 h / 80 °C

4: potassium carbonate / N,N-dimethyl-formamide / 50 °C

5: water; acetonitrile

6: dichloromethane / 20 °C

7: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

8: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

9: water; acetonitrile

10: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

11: water; acetonitrile

12: dichloromethane / 20 °C

13: potassium tert-butylate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 872-53-7
cyclopentanealdehyde

: 1055925-77-3
N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yI}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

Guidance literature:: Multi-step reaction with 14 steps

1.1: sodium cyanoborohydride; acetic acid / methanol / 20 °C

1.2: 0 °C

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 6 h / Heating / reflux

3.1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 2 h / 150 °C

4.1: dowex 50x2-200 ion exchange resin / ethanol / 1 h / 80 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

6.1: water; acetonitrile

7.1: dichloromethane / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

10.1: water; acetonitrile

11.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

12.1: water; acetonitrile

13.1: dichloromethane / 20 °C

14.1: potassium tert-butylate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; sodium cyanoborohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;