Technology Process of C18H19NO3
There total 6 articles about C18H19NO3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-methylphenylmethylazide; methyl 2-formyl-4,6-dimethoxybenzoate;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
With
sodium cyanoborohydride;
In
tetrahydrofuran;
for 12h;
Inert atmosphere;
Reflux;
DOI:10.1039/c3cc43838d
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sec.-butyllithium; N,N,N,N,-tetramethylethylenediamine / -78 °C
2.1: acetic acid; hydrogenchloride / 12 h / Reflux
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C
4.1: polymerbounded triphenylphosphine / tetrahydrofuran / 3 h / 20 °C
4.2: 12 h / Inert atmosphere; Reflux
With
hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; acetonitrile;
4.1: |Aza-Wittig Reaction;
DOI:10.1039/c3cc43838d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic acid; hydrogenchloride / 12 h / Reflux
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C
3.1: polymerbounded triphenylphosphine / tetrahydrofuran / 3 h / 20 °C
3.2: 12 h / Inert atmosphere; Reflux
With
hydrogenchloride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; acetonitrile;
3.1: |Aza-Wittig Reaction;
DOI:10.1039/c3cc43838d
