17271-89-5

Usage

Uses

Used in Organic Chemistry:
1-(azidomethyl)-4-methylbenzene(SALTDATA: FREE) is used as a reagent or precursor for the production of other compounds in organic chemistry. Its unique azido group allows for various chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 1-(azidomethyl)-4-methylbenzene(SALTDATA: FREE) is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity enable the development of new drugs with specific therapeutic properties.
Used in Agrochemical Production:
1-(azidomethyl)-4-methylbenzene(SALTDATA: FREE) is also employed in the agrochemical industry as a precursor for the synthesis of various agrochemicals, such as pesticides and herbicides. Its versatility in chemical reactions allows for the development of effective and targeted agrochemicals.
Used in Industrial Product Synthesis:
In the industrial sector, 1-(azidomethyl)-4-methylbenzene(SALTDATA: FREE) is utilized as a building block for the synthesis of various industrial products, including dyes, polymers, and other specialty chemicals. Its unique properties and reactivity contribute to the development of innovative and high-performance materials.

Upstream product

• 18991-39-4 p-methylbenzyl thiocyanate 
• 72538-32-0 1-(4-methylbenzyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate 
• 4648-54-8 trimethylsilylazide 
• 104-81-4 4-Methylbenzyl bromide 
• 78358-10-8 4-methylbenzyl mesylate 
• 104-82-5 4-Methylbenzyl chloride 
• 108-88-3 toluene 
• 106-42-3 para-xylene 
• 160732-56-9 1-azido-1λ³-benzo[d][1,2]iodaoxol-3(1H)-one 
• 104-84-7 para-methylbenzylamine 
• 104-87-0 4-methyl-benzaldehyde 
• 589-18-4 4-Methylbenzyl alcohol 
• 87976-56-5 3-Cyano-1-(4-methyl-benzyl)-pyridinium; chloride 
• 132907-18-7 3,6-dimethoxy-3,6-dimethylcyclohexa-1,4-diene 

Downstream Products

• 141071-95-6 di-tert-butyl 1-(4-methylbenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate 
• 141072-08-4 methyl 1-(4-methylbenzyl)-1H-1,2,3-triazole-4-carboxylate 
• 126799-89-1 dimethyl 1-(4-methylbenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate 
• 126800-26-8 1-(4-methylbenzyl)-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester 
• 50-00-0 formaldehyd 
• 7664-41-7 ammonia 
• 104-87-0 4-methyl-benzaldehyde 
• 106-49-0 p-toluidine 
• 64309-86-0 tris-(4-methylbenzyl)-amine 
• 126800-02-0 1-(4-methylbenzyl)-4-phenyl-1H-1,2,3-triazole 
• 104504-73-6 methyl 2-carbomethoxy-3--propenoate 
• 104504-74-7 methyl 2-carbomethoxy-3--propenoate 
• 930091-67-1 [Re(carbonyl)3(PPh(OEt)2)2(NHCH(4-C₆H₄CH₃))]BPh₄ 
• 930091-45-5 [Re(carbonyl)2(η2-1,4-(4-CH3C6H4CH2)2N4)(PPh(OEt)2)2]BPh4 

Relevant academic research and scientific papers

Identification of Phenylphthalazinones as a New Class of Leishmania infantum Inhibitors

Leishmaniasis is a neglected parasitic disease caused by over 20 different Leishmania species. Current treatments often rely on harsh regimes of pentavalent antimonials such as sodium stibogluconate, while more recent drugs suffer other shortcomings such

An expedient and highly selective conversion of alcohols to azides using a NaN3/BF3·Et2O system

Alkyl azides were prepared in good yields by treatment of allylic and benzylic alcohols with a molar equivalent of NaN3 in the presence of BF3·Et2O in dioxane.

REACTION OF TRIMETHYLSILYL AZIDE WITH ORGANIC HALIDES

Trimethylsilyl azide reacted readily with benzyl, allyl, and aliphatic halides to give the corresponding azides in good to excellent yields.

Application of magnetic dicationic ionic liquid phase transfer catalyst in nuclophilic substitution ractions of benzyl halides in water

Magnetic dicationic ionic liquid (MDIL) was successfully prepared and evaluated as phase-transfer catalyst for nucleophilic substitution reactions. The reactions was occurred in water and furnished the corresponding benzyl derivatives in high yields. No evidence for the formation of by-product for example benzyl alcohol of the reaction was observed and the products were obtained in pure form without further purification.

Interrupted CuAAC-Thiolation for the Construction of 1,2,3-Triazole-Fused Eight-Membered Heterocycles from O-/N-Propargyl derived Benzyl Thiosulfonates with Organic Azides

A copper(I)-catalyzed interrupted click-sulfenylation of O-/N-propargyl benzyl thiosulfonates with organic azides has been disclosed. The unified CuAAC-thiolation provides a wide range of triazole-fused eight-membered heterocycles in good to high (51–94%) yields under mild reaction conditions. Moreover, a three-component reaction is also achieved involving O-/N-propargyl benzyl thiosulfonates, benzyl bromide, and sodium azide to deliver fused-triazoles in 61–74% yields. From a synthetic point of view, the present protocol has been demonstrated at gram-scale reactions. A plausible mechanism is also proposed based on experimental results and control experiments. (Figure presented.).

Synthesis and Evaluation of Bakuchiol Derivatives as Potent Anti-inflammatory Agents in Vitro and in Vivo

Bakuchiol, a prenylated phenolic monoterpene derived from the fruit of Psoralen corylifolia L. (Buguzhi), is widely used to treat tumors, viruses, inflammation, and bacterial infections. In this study, we designed and synthesized 30 bakuchiol derivatives

Synthesis of Azido-Dienediols by Enzymatic Dioxygenation of Benzylazides: An Experimental and Theoretical Study

Allylic azides are versatile structural motifs in organic synthesis because the proximal double bond enables a [3,3]-sigmatropic rearrangement, named as the Winstein rearrangement. In this work, an experimental and theoretical study on the double Winstein rearrangement occurring in azidodienediols derived from the biocatalytic dihydroxylation of substituted benzylazides is presented. Substrates bearing a methyl group at the ortho or meta position produced exclusively rearranged exo-diendiols with the azide group anti to the diol moiety as the major constituent. In the case of para methyl substrates, an equilibrium mixture of rearranged and non-rearranged products was observed, indicating that a full conversion to the exo-dienediols is not possible within this substitution pattern. On the other hand, the presence of a chloro substituent in the diene moiety completely precluded the Winstein rearrangement to take place, giving rise exclusively to the traditional cis-cyclohexadienediols. The observed results were analyzed to determine the mechanistic and kinetic aspects and scope limitations of the reaction as a synthetic tool.

Synthesis and comparison of in vitro dual anti-infective activities of novel naphthoquinone hybrids and atovaquone

A principal factor that contributes towards the failure to eradicate leishmaniasis and tuberculosis infections is the reduced efficacy of existing chemotherapies, owing to a continuous increase in multidrug-resistant strains of the causative pathogens. Th

NOVEL DIBENZOOXAPHOSPHININE OXIDE DERIVATIVE COMPOUNDS AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DEGENERATIVE DISEASE COMPRISING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to a novel dibenzooxininin oxide derivative compound having various nitrogen-containing substituents introduced at 6-position of a dibenzooxaphosphorin oxide mononuclear, and to the use thereof. The present invention relates to a pharmaceutical composition for preventing or treating degenerative diseases and a health supplement food composition for preventing or treating degenerative diseases, comprising the dibenzooxaphosphorin oxide derivative compound of the present invention.

Dipolar HCP materials as alternatives to DMF solvent for azide-based synthesis

Hypercrosslinked polymers HCP-DMF and HCP-DMF-SO3H containing abundant and flexible DMF moieties were designed and synthesized. Benefitting from the solvation microenvironment provided by the pseudo-DMF moities, the polar HCPs manifested outstanding performances in the conversions of NaN3 to benzylic azides and 1,2,3-triazoles in EtOH (95%), respectively, avoiding the use of risky DMF and improving the separation processes of the products.