N-(4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl)-2-nitrobenzaMide

Base Information

• Chemical Name: N-(4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl)-2-nitrobenzaMide
• CAS No.: 82924-82-1
• Molecular Formula: C₁₉H₂₀N₂O₅
• Molecular Weight: 356.378
• Mol file: 82924-82-1.mol

Synonyms:1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-nitro-phenyl)-ethanone

Chemical Property of N-(4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl)-2-nitrobenzaMide

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

6,7-Dimethoxy-2-[(4-nitrophenyl)acetyl]-1,2,3,4-tetrahydroisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl)-2-nitrobenzaMide

There total 2 articles about N-(4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl)-2-nitrobenzaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitrobenzeneacetic acid (104-03-0) → 1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-nitro-phenyl)-ethanone (82924-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 3 h / Heating

2: NaHCO₃ / acetone / 6 h / Ambient temperature

With thionyl chloride; sodium hydrogencarbonate; In acetone;

DOI:10.1021/jm00013a017

Reference yield:

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (1745-07-9) + 4-nitrophenylacetyl chloride (50434-36-1) → 1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-nitro-phenyl)-ethanone (82924-82-1)

Guidance literature:

With sodium hydrogencarbonate; In acetone; for 6h; Ambient temperature;

DOI:10.1021/jm00013a017

Reference yield:

1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-nitro-phenyl)-ethanone (82924-82-1) → 2-(4-Amino-phenyl)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone (1018524-30-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00013a017

upstream raw materials:

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

4-nitrophenylacetyl chloride

4-nitrobenzeneacetic acid

Downstream raw materials:

2-(4-Amino-phenyl)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone

4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine

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