<<(3S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninal diamide

Base Information

Chemical Name:<<(3S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninal diamide
CAS No.:145525-29-7
Molecular Formula:C₃₂H₄₀N₂O₅S
Molecular Weight:564.746
Hs Code.:

Synonyms:<<(3S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninal diamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <<(3S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninal diamide

Chemical Property:

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Technology Process of <<(3S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninal diamide

There total 8 articles about <<(3S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninal diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 176692-32-3
<<3(S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninol diamide

: 145525-29-7
<<(3S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninal diamide

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 ℃;

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 145525-29-7
<<(3S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninal diamide

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / NEt₃, n-propyl phosphonic acid anhydride / CH₂Cl₂; ethyl acetate / 3 h / 0 - 20 °C

2: 91 percent / HCl gas / methanol / 2 h

3: 74 percent / NEt₃, N,N'-dicyclohexylcarbodiimide / ethyl acetate / 2 h / 45 °C

4: 72 percent / oxalyl chloride, DMSO, NEt₃ / CH₂Cl₂ / 1 h / -60 °C

With hydrogenchloride; oxalyl dichloride; propylphosphonic anhydride; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 145525-29-7
<<(3S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninal diamide

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / NEt₃, n-propyl phosphonic acid anhydride / CH₂Cl₂; ethyl acetate / 3 h / 0 - 20 °C

2: 91 percent / HCl gas / methanol / 2 h

3: 74 percent / NEt₃, N,N'-dicyclohexylcarbodiimide / ethyl acetate / 2 h / 45 °C

4: 72 percent / oxalyl chloride, DMSO, NEt₃ / CH₂Cl₂ / 1 h / -60 °C

With hydrogenchloride; oxalyl dichloride; propylphosphonic anhydride; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; ethyl acetate;