phenyl N-{[benzyl(2-hydroxy-2-phenylethyl)carbamoyl]-methyl}-N-methylcarbamate

Base Information

• Chemical Name: phenyl N-{[benzyl(2-hydroxy-2-phenylethyl)carbamoyl]-methyl}-N-methylcarbamate
• CAS No.: 1375744-61-8
• Molecular Formula: C₂₅H₂₆N₂O₄
• Molecular Weight: 418.492
• Mol file: 1375744-61-8.mol

Synonyms:phenyl N-{[benzyl(2-hydroxy-2-phenylethyl)carbamoyl]-methyl}-N-methylcarbamate

Chemical Property of phenyl N-{[benzyl(2-hydroxy-2-phenylethyl)carbamoyl]-methyl}-N-methylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl N-{[benzyl(2-hydroxy-2-phenylethyl)carbamoyl]-methyl}-N-methylcarbamate

There total 1 articles about phenyl N-{[benzyl(2-hydroxy-2-phenylethyl)carbamoyl]-methyl}-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

phenyl (2-chloro-2-oxoethyl)methylcarbamate (1096711-35-1) + 2-benzylamino-1-phenyl-ethanol (51096-49-2,91579-12-3,107171-75-5,27159-30-4) → phenyl N-{[benzyl(2-hydroxy-2-phenylethyl)carbamoyl]-methyl}-N-methylcarbamate (1375744-61-8)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; water; at 0 ℃;

DOI:10.1021/jo3007144

Reference yield: 94.0%

phenyl N-{[benzyl(2-hydroxy-2-phenylethyl)carbamoyl]-methyl}-N-methylcarbamate (1375744-61-8) → phenyl N-{[benzyl(2-oxo-2-phenylethyl)carbamoyl]methyl}-N-methylcarbamate (1375744-62-9)

Guidance literature:

With sodium acetate; pyridinium chlorochromate; In dichloromethane; at 0 ℃; Molecular sieve;

DOI:10.1021/jo3007144

Reference yield:

phenyl N-{[benzyl(2-hydroxy-2-phenylethyl)carbamoyl]-methyl}-N-methylcarbamate (1375744-61-8) → 3-benzoyl-4-benzyl-1-methylpiperazine-2,5-dione (1375744-63-0) + 1-methyl-3-(phenylmethyl)-2,4-imidazolidinedione (34658-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate; pyridinium chlorochromate / dichloromethane / 0 °C / Molecular sieve

2: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 70 °C

With sodium acetate; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; mineral oil; 2: Dieckmann cyclization;

DOI:10.1021/jo3007144

upstream raw materials:

phenyl (2-chloro-2-oxoethyl)methylcarbamate

2-benzylamino-1-phenyl-ethanol

Downstream raw materials:

3-benzoyl-4-benzyl-1-methylpiperazine-2,5-dione

1-methyl-3-(phenylmethyl)-2,4-imidazolidinedione

phenyl N-{[benzyl(2-oxo-2-phenylethyl)carbamoyl]methyl}-N-methylcarbamate