1-((4R,5R)-5-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

Base Information

Chemical Name:1-((4R,5R)-5-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone
CAS No.:1454907-31-3
Molecular Formula:C₂₁H₂₁F₆N₃O₂
Molecular Weight:461.407
Hs Code.:

Synonyms:1-((4R,5R)-5-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

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Chemical Property of 1-((4R,5R)-5-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

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Technology Process of 1-((4R,5R)-5-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

There total 9 articles about 1-((4R,5R)-5-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454907-30-2
1-((4R,5R)-5-{4-[6-(1-benzylamino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

: 1454907-31-3
1-((4R,5R)-5-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 16h;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1454907-31-3
1-((4R,5R)-5-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -78 °C

1.2: 0.5 h / -78 °C

2.1: titanium(IV) tetraethanolate / toluene / 3 h / 20 °C

3.1: sodium tris(acetoxy)borohydride / methanol / 3 h / 0 - 20 °C

4.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 3 h / 80 °C / Inert atmosphere

5.1: hydrogen; palladium on activated charcoal / methanol / 16 h / 20 °C

With titanium(IV) tetraethanolate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; palladium on activated charcoal; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; In tetrahydrofuran; methanol; ethanol; hexane; water; toluene;

Reference yield:

: 1454907-28-8
benzyl-[1-(5-brompyridin-2-yl)-2,2,2-trifluoroeth-(E)-ylidene]amine

: 1454907-31-3
1-((4R,5R)-5-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / methanol / 3 h / 0 - 20 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 3 h / 80 °C / Inert atmosphere

3: hydrogen; palladium on activated charcoal / methanol / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; In methanol; ethanol; water; toluene;