1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone

Base Information

• Chemical Name: 1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone
• CAS No.: 886364-50-7
• Molecular Formula: C7H3BrF3NO
• Molecular Weight: 254.00
• Mol file: 886364-50-7.mol

Synonyms:1-(5-BROMOPYRIDIN-2-YL)-2,2,2-TRIFLUOROETHAN-1-ONE;1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone;

Chemical Property of 1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone

Chemical Property:

• Boiling Point: 236 oC
• PKA: -1.40±0.10(Predicted)
• Flash Point: 97 oC
• PSA: 29.96000
• Density: 1.730
• LogP: 2.58910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(5-Bromopyridin-2-yl)-2,2,2-trifluoroethanone 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone

There total 4 articles about 1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(5-bromo-pyridin-2-yl)-2,2,2-trifluoroethanol (917397-92-3) → 1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanone (886364-50-7)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; for 18h; Reflux;

DOI:10.1016/j.tetlet.2013.06.045

Reference yield:

2,2,2-trifluoroethyl trifluoroacetate (407-38-5) → 1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanone (886364-50-7)

Guidance literature:

2,5-dibromopyridine; With n-butyllithium; In hexanes; toluene; at -78 ℃; for 0.5h;

2,2,2-trifluoroethyl trifluoroacetate; In hexanes; toluene; at -78 ℃; for 2.25h;

With water; ammonium chloride; In hexanes; toluene;

Reference yield:

2,5-dibromopyridine (624-28-2) + ethyl trifluoroacetate, (383-63-1) → 1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanone (886364-50-7)

Guidance literature:

2,5-dibromopyridine; With n-butyllithium; In tetrahydrofuran; hexane; toluene; at -78 ℃;

ethyl trifluoroacetate,; In tetrahydrofuran; hexane; toluene; at -78 ℃; for 0.5h;

upstream raw materials:

2,2,2-trifluoroethyl trifluoroacetate

5-bromo-pyridine-2-carbaldehyde

1-(5-bromo-pyridin-2-yl)-2,2,2-trifluoroethanol

2,5-dibromopyridine

Downstream raw materials:

benzyl[1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethyl]amine

1-((4R,5R)-5-{4-[6-(1-benzylamino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

1-((4R,5R)-5-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

N-((1S,2R)-2-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-1-fluoromethyl-2-hydroxyethyl)-2,2-difluoroacetamide