Thiazosulfone

Base Information

• Chemical Name: Thiazosulfone
• CAS No.: 473-30-3
• Molecular Formula: C9H9 N3 O2 S2
• Molecular Weight: 255.321
• NSC Number: 1884
• UNII: WE45JZI7YO
• DSSTox Substance ID: DTXSID80197088
• Nikkaji Number: J2.052D
• Wikidata: Q27292585
• NCI Thesaurus Code: C152587
• Metabolomics Workbench ID: 155854
• ChEMBL ID: CHEMBL2107139
• Mol file: 473-30-3.mol

Synonyms:2-amino-5-sulfanilylthiazole;promizole;thiazolsulfone;thiazosulfone

Chemical Property of Thiazosulfone

Chemical Property:

• Vapor Pressure: 1.55E-12mmHg at 25°C
• Melting Point: 219-221° (some decompn)
• Refractive Index: 1.6740 (estimate)
• Boiling Point: 559.2°Cat760mmHg
• Flash Point: 292°C
• PSA: 135.69000
• Density: 1.546g/cm³
• LogP: 3.38350
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 255.01361889
• Heavy Atom Count: 16
• Complexity: 333

Purity/Quality:

99% ^*data from raw suppliers

5-[(4-AMINOPHENYL)SULFONYL]-2-THIAZOLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1N)S(=O)(=O)C2=CN=C(S2)N
• Uses: Promizole(Parke-Davis).

Technology Process of Thiazosulfone

There total 11 articles about Thiazosulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-[(4-nitrophenyl)sulfonyl]-1,3-thiazol-2-amine (39565-05-4) → thiazosulfone (473-30-3)

Guidance literature:

With potassium fluoride; polymethylhydrosiloxane; palladium diacetate; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

DOI:10.1055/s-2006-950231

Reference yield:

5-[(4-nitrophenyl)sulfonyl]-1,3-thiazol-2-amine (39565-05-4) + iron (7439-89-6) → thiazosulfone (473-30-3)

Guidance literature:

With ammonium chloride; In tetrahydrofuran; ethanol; water;

Reference yield:

N-[5-(4-nitro-benzenesulfonyl)-thiazol-2-yl]-acetamide (7354-88-3) → thiazosulfone (473-30-3)

Guidance literature:

With methanol; 2-ethoxy-ethanol; nickel; Hydrogenation_.anschliessend Erwaermen mit HCl;

DOI:10.1039/jr9470000110

upstream raw materials:

5-[(4-nitrophenyl)sulfonyl]-1,3-thiazol-2-amine

N-[4-(2-amino-thiazole-5-sulfonyl)-phenyl]-acetamide

2-acetylamino-5-(4-acetylamino-benzenesulfonyl)-thiazole

N-[5-(4-nitro-benzenesulfonyl)-thiazol-2-yl]-acetamide

Downstream raw materials:

(dichloro-[1,3,5]triazin-2-yl)-(5-sulfanilyl-thiazol-2-yl)-amine

2-acetylamino-5-(4-acetylamino-benzenesulfonyl)-thiazole

1-(3-bromo-propionyl)-3-(5-{4-[3-(3-bromo-propionyl)-ureido]-benzenesulfonyl}-thiazol-2-yl)-urea

1-[4-(2-amino-thiazole-5-sulfonyl)-phenyl]-3-(3-bromo-propionyl)-urea

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