3-(1-Methoxymethyl-6-oxo-3-phenyl-1,6-dihydropyridazin-4-yl)propinoic acid

Base Information

Chemical Name:3-(1-Methoxymethyl-6-oxo-3-phenyl-1,6-dihydropyridazin-4-yl)propinoic acid
CAS No.:247158-84-5
Molecular Formula:C₁₅H₁₂N₂O₄
Molecular Weight:284.271
Hs Code.:

Synonyms:3-(1-Methoxymethyl-6-oxo-3-phenyl-1,6-dihydropyridazin-4-yl)propinoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(1-Methoxymethyl-6-oxo-3-phenyl-1,6-dihydropyridazin-4-yl)propinoic acid

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Technology Process of 3-(1-Methoxymethyl-6-oxo-3-phenyl-1,6-dihydropyridazin-4-yl)propinoic acid

There total 2 articles about 3-(1-Methoxymethyl-6-oxo-3-phenyl-1,6-dihydropyridazin-4-yl)propinoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 247158-79-8
5-Bromo-2-methoxymethyl-6-phenylpyridazin-3-one

: 471-25-0
Propiolic acid

: 247158-84-5
3-(1-Methoxymethyl-6-oxo-3-phenyl-1,6-dihydropyridazin-4-yl)propinoic acid

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; at 70 ℃; for 4h;
DOI:10.1055/s-1999-3567

Reference yield:

: 90766-97-5
5-bromo-6-phenylpyridazin-3(2H)-one

: 247158-84-5
3-(1-Methoxymethyl-6-oxo-3-phenyl-1,6-dihydropyridazin-4-yl)propinoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / DMAP; i-Pr₂NEt / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 70 percent / Et₃N / Pd(PPh₃)2Cl₂; CuI / CH₂Cl₂ / 4 h / 70 °C

With dmap; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; 1: Alkylation / 2: Alkylation;
DOI:10.1055/s-1999-3567