90766-97-5

Usage

Uses

Used in Medicinal Chemistry:
5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE is used as a building block for the synthesis of pharmaceutical drugs due to its unique structure and properties. It contributes to the development of biologically active compounds that can be utilized in the treatment of various diseases and conditions.
Used in Agrochemicals:
In the agrochemical industry, 5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE may be employed as a component in the formulation of pesticides, herbicides, or other agricultural chemicals. Its specific role would depend on further research into its chemical properties and interactions with biological systems.
Used in Materials Science:
5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE could be utilized in the field of materials science for the development of new materials with unique properties. Its potential applications may include the creation of advanced polymers, sensors, or other innovative materials that leverage its chemical structure.
As ongoing research and investigation into the compound's potential uses and properties continue, it is likely that additional applications will be identified, further expanding the utility of 5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE across various industries.

InChI:InChI=1/C10H7BrN2O/c11-8-6-9(14)12-13-10(8)7-4-2-1-3-5-7/h1-6H,(H,12,14)

Upstream product

• 72857-86-4 α,β-dibromo-γ-phenylcrotonolactone 
• 491876-40-5 5-bromo-2-hydroxymethyl-6-phenyl-3(2H)-pyridazinone 

Downstream Products

• 220967-35-1 6-phenyl-5-piperidinyl-3(2H)-pyridazinone 
• 132814-16-5 6-phenyl-5-(N¹-piperazinyl)-2H-pyridazin-3-one 
• 247158-79-8 5-Bromo-2-methoxymethyl-6-phenylpyridazin-3-one 
• 87769-63-9 5-amino-6-phenyl-1,6-dihydropyridazin-3(2H)-one 
• 252920-09-5 5-cyano-6-phenyl-3(2H)-pyridazinone 
• 433935-99-0 5-bromo-6-chloro-3-phenylpyridazine 
• 473934-57-5 5-methylthio-6-phenyl-3(2H)-pyridazinone 
• 473934-67-7 5-bromo-2-methyl-6-phenyl-2,3-dihydropyridazin-3-one 
• 499783-15-2 6-phenyl-5-phenylthio-3(2H)-pyridazinone 
• 701975-47-5 3-[1-(2-cyanoethyl)-6-oxo-3-phenyl-1,6-dihydropyridazin-4-yl]acrylonitrile 
• 1233943-70-8 5-(3-methoxyphenyl)-6-phenylpyridazin-3(2H)-one 
• 442123-58-2 5-methylsulfonyl-6-phenyl-3(2H)-pyridazinone 
• 617693-71-7 2-methoxymethyl-6-phenyl-5-[(1'-ethoxy)vinyl]-3-pyridazinone 
• 499783-14-1 5-(1'-hydroxyethyl)-2-methoxymethyl-6-phenyl-3(2H)-pyridazinone 

Relevant academic research and scientific papers

Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat

The design and synthesis of two closely related series of prostacyclin receptor agonist compounds that showed excellent human IP receptor potency and efficacy is described. Compounds from this series showed in vivo activity after SC dosing in the monocrotaline model of PAH in rat.

MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO

Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: p

Pyridazines. Part 35: Traceless solid phase synthesis of 4,5- and 5,6-diaryl-3(2H)-pyridazinones

A new method for the traceless solid phase synthesis of 3(2H)-pyridazinones has been developed employing dihydropyran-functionalized resin. The procedure has permitted the preparation of several diarylpyridazinones through a Suzuki cross-coupling reaction and cleavage conditions that promoted a retro-ene fragmentation.

Pyridazines. Part XXIX: Synthesis and platelet aggregation inhibition activity of 5-substituted-6-phenyl-3(2H)-pyridazinones. Novel aspects of their biological actions

A series of 6-phenyl-3(2H)-pyridazinones with a diverse range of substituents in the 5-position have been prepared and evaluated in the search for new antiplatelet agents. A significant dependence of the substituent on the inhibitory effect has been observed. The pharmacological study of these compounds confirms that modification of the chemical group at position 5 of the 6-phenyl-3(2H)-pyridazinone system influences both variations in the antiplatelet activity and the mechanism of action.

Pyridazines. XV. Synthesis of 6-aryl-5-amino-3(2H)-pyridazinones as potential platelet aggregation inhibitors

Several 3(2H)-pyridazinones with amino groups at the 5-position of the pyridazine nucleus have been prepared. The 6-aryl-5-halo-3(2H)-pyridazinones obtained from mucochloric and mucobromic acid lead to the corresponding 5- alkylamino-3(2H)-pyridazinones,