5,5-dimethyl-3-(4-trimethylsilylbut-3-ynyl)cyclohex-2-en-1-ol

Base Information

• Chemical Name: 5,5-dimethyl-3-(4-trimethylsilylbut-3-ynyl)cyclohex-2-en-1-ol
• CAS No.: 121079-99-0
• Molecular Formula: C₁₅H₂₆OSi
• Molecular Weight: 250.456
• Mol file: 121079-99-0.mol

Synonyms:5,5-dimethyl-3-(4-trimethylsilylbut-3-ynyl)cyclohex-2-en-1-ol

Chemical Property of 5,5-dimethyl-3-(4-trimethylsilylbut-3-ynyl)cyclohex-2-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,5-dimethyl-3-(4-trimethylsilylbut-3-ynyl)cyclohex-2-en-1-ol

There total 4 articles about 5,5-dimethyl-3-(4-trimethylsilylbut-3-ynyl)cyclohex-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5,5-dimethyl-3-(4-trimethylsilylbut-3-ynyl)cyclohex-2-enone (121079-98-9) → 5,5-dimethyl-3-(4-trimethylsilylbut-3-ynyl)cyclohex-2-en-1-ol (121079-99-0)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -20 ℃; for 3h;

DOI:10.1016/S0040-4020(01)80475-0

Reference yield:

3-methoxy-5,5-dimethyl-cyclohex-2-enone (4683-45-8) → 5,5-dimethyl-3-(4-trimethylsilylbut-3-ynyl)cyclohex-2-en-1-ol (121079-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 2.) H₃O⁽¹⁺⁾

2: 88 percent / di-isobutylaluminiumhydride

With diisobutylaluminum hydride; oxonium;

DOI:10.1039/c39880001380

Reference yield:

4-iodo-1-butynyltrimethylsilane (41423-29-4) → 5,5-dimethyl-3-(4-trimethylsilylbut-3-ynyl)cyclohex-2-en-1-ol (121079-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) t-BuLi / 1) pentane, -78 deg C, 1 h , 2) THF, -78 deg C, 1 h

2: 88 percent / DIBAL / toluene / 3 h / -20 °C

With tert.-butyl lithium; diisobutylaluminium hydride; In toluene;

DOI:10.1016/S0040-4020(01)80475-0

upstream raw materials:

5,5-dimethyl-3-(4-trimethylsilylbut-3-ynyl)cyclohex-2-enone

3-methoxy-5,5-dimethyl-cyclohex-2-enone

4-lithio-1-trimethylsilylbut-1-yne

4-iodo-1-butynyltrimethylsilane

Downstream raw materials:

5,5,6-trimethyl-3-(4-trimethylsilylbut-3-ynyl)cyclohex-2-enone

benzoic acid <(1RS,6SR)-5,5,6-trimethyl-3-(4-trimethylsilylbut-3-ynyl)-cyclohex-2-enyl>ester

(1RS,6RS)-5,5,6-trimethyl-3-(4-trimethylsilylbut-3-ynyl)-cyclohex-2-en-1-ol

(1RS,6SR)-5,5,6-trimethyl-3-(4-trimethylsilylbut-3-ynyl)-cyclohex-2-en-1-ol