(4S)-4-[([4-{(2S,5S,3R,4R,6R)-6-[(benzyloxy)methyl]-3,4,5-tribenzyloxy}perhydro-2H-pyran-2-yl]methyl)phenyl]-1-(4-fluorophenyl)azetidine-2-one

Base Information

Chemical Name:(4S)-4-[([4-{(2S,5S,3R,4R,6R)-6-[(benzyloxy)methyl]-3,4,5-tribenzyloxy}perhydro-2H-pyran-2-yl]methyl)phenyl]-1-(4-fluorophenyl)azetidine-2-one
CAS No.:452068-50-7
Molecular Formula:C₅₀H₄₈FNO₆
Molecular Weight:777.933
Hs Code.:

Synonyms:(4S)-4-[([4-{(2S,5S,3R,4R,6R)-6-[(benzyloxy)methyl]-3,4,5-tribenzyloxy}perhydro-2H-pyran-2-yl]methyl)phenyl]-1-(4-fluorophenyl)azetidine-2-one

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Chemical Property of (4S)-4-[([4-{(2S,5S,3R,4R,6R)-6-[(benzyloxy)methyl]-3,4,5-tribenzyloxy}perhydro-2H-pyran-2-yl]methyl)phenyl]-1-(4-fluorophenyl)azetidine-2-one

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Technology Process of (4S)-4-[([4-{(2S,5S,3R,4R,6R)-6-[(benzyloxy)methyl]-3,4,5-tribenzyloxy}perhydro-2H-pyran-2-yl]methyl)phenyl]-1-(4-fluorophenyl)azetidine-2-one

There total 1 articles about (4S)-4-[([4-{(2S,5S,3R,4R,6R)-6-[(benzyloxy)methyl]-3,4,5-tribenzyloxy}perhydro-2H-pyran-2-yl]methyl)phenyl]-1-(4-fluorophenyl)azetidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.4%

: 452068-49-4
4-[[(2S)-1-(4-fluorophenyl)-4-oxoazetidine-2-yl]phenyl]trifluoromethanesulfonate

: 133697-34-4,97321-70-5
2,6-anhydro-3,4,5,7-tetra-O-benzyl-1-deoxy-D-gluco-hept-1-enitol

: 452068-50-7
(4S)-4-[([4-{(2S,5S,3R,4R,6R)-6-[(benzyloxy)methyl]-3,4,5-tribenzyloxy}perhydro-2H-pyran-2-yl]methyl)phenyl]-1-(4-fluorophenyl)azetidine-2-one

Guidance literature:: 4-[[(2S)-1-(4-fluorophenyl)-4-oxoazetidine-2-yl]phenyl]trifluoromethanesulfonate; With 9-borabicyclo[3.3.1]nonane; In tetrahydrofuran; for 6h; Heating / reflux;

2,6-anhydro-3,4,5,7-tetra-O-benzyl-1-deoxy-D-gluco-hept-1-enitol; With potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water; at 20 - 50 ℃; for 16h;

Reference yield: 71.8%

: 452068-50-7
(4S)-4-[([4-{(2S,5S,3R,4R,6R)-6-[(benzyloxy)methyl]-3,4,5-tribenzyloxy}perhydro-2H-pyran-2-yl]methyl)phenyl]-1-(4-fluorophenyl)azetidine-2-one

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 452068-51-8
methyl 3-{[{(4S,3R)-4-[4-{(2S,5S,3R,4R,6R)-6-(benzyloxymethyl)-3,4,5-tribenzyloxy} perhydro-2H-pyran-2-yl]methyl}phenyl]-1-(4-fluorophenyl)oxoazetidine-3-yl}propionate

Guidance literature:: (4S)-4-[([4-{(2S,5S,3R,4R,6R)-6-[(benzyloxy)methyl]-3,4,5-tribenzyloxy}perhydro-2H-pyran-2-yl]methyl)phenyl]-1-(4-fluorophenyl)azetidine-2-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

acrylic acid methyl ester; In tetrahydrofuran; for 0.5h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield: 64.4%

: 452068-50-7
(4S)-4-[([4-{(2S,5S,3R,4R,6R)-6-[(benzyloxy)methyl]-3,4,5-tribenzyloxy}perhydro-2H-pyran-2-yl]methyl)phenyl]-1-(4-fluorophenyl)azetidine-2-one

: 53041-12-6
1-[(E)-3-bromo-1-propenyl]-4-fluorobenzene

: 452068-53-0
(4S,3R)-4-[4-{(2S,5S,3R,4R,6R)-6-[(benzyloxy)methyl]-3,4,5-tribenzyloxy}perhydro-2H-pyran-2-yl]methylphenyl-1-[(4-fluorophenyl)-2-propenyl]azetidin-2-one

Guidance literature:: (4S)-4-[([4-{(2S,5S,3R,4R,6R)-6-[(benzyloxy)methyl]-3,4,5-tribenzyloxy}perhydro-2H-pyran-2-yl]methyl)phenyl]-1-(4-fluorophenyl)azetidine-2-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; for 0.5h;

1-[(E)-3-bromo-1-propenyl]-4-fluorobenzene; With ammonium chloride; more than 3 stages;