Technology Process of (S)-2-(1-benzylpiperidin-2-yl)ethanol
There total 5 articles about (S)-2-(1-benzylpiperidin-2-yl)ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
acetonitrile;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / -30 °C
1.2: 16 h / -30 - 20 °C
2.1: silver benzoate / 16 h / 20 °C / Cooling with ice
3.1: dichloromethane / 4 h / 20 °C / Cooling with ice
4.1: potassium carbonate / acetonitrile / 0.25 h / 20 °C / Cooling with ice
4.2: 16 h / 100 °C
5.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 4 h / -30 - 5 °C
5.2: -50 °C
With
4-methyl-morpholine; diisobutylaluminium hydride; potassium carbonate; isobutyl chloroformate;
silver benzoate;
In
tetrahydrofuran; dichloromethane; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: silver benzoate / 16 h / 20 °C / Cooling with ice
2.1: dichloromethane / 4 h / 20 °C / Cooling with ice
3.1: potassium carbonate / acetonitrile / 0.25 h / 20 °C / Cooling with ice
3.2: 16 h / 100 °C
4.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 4 h / -30 - 5 °C
4.2: -50 °C
With
diisobutylaluminium hydride; potassium carbonate;
silver benzoate;
In
tetrahydrofuran; dichloromethane; toluene; acetonitrile;
