1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-fluorophenyl}-3-methyl-2-imidazolidinone

Base Information

Chemical Name:1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-fluorophenyl}-3-methyl-2-imidazolidinone
CAS No.:871737-39-2
Molecular Formula:C₂₄H₂₈FN₃O₂
Molecular Weight:409.504
Hs Code.:

Synonyms:1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-fluorophenyl}-3-methyl-2-imidazolidinone

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Chemical Property of 1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-fluorophenyl}-3-methyl-2-imidazolidinone

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Technology Process of 1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-fluorophenyl}-3-methyl-2-imidazolidinone

There total 7 articles about 1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-fluorophenyl}-3-methyl-2-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 694-32-6
1-methyl-2-imidazolidone

: 3-cyclobutyl-7-[(2-fluoro-4-iodophenyl)oxy]-2,3,4,5-tetrahydro-1H-3-benzazepine

: 871737-39-2
1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-fluorophenyl}-3-methyl-2-imidazolidinone

Guidance literature:: With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 140 ℃; for 1h;

Reference yield:

: 149354-10-9
3-(tert-butyloxycarbonyl)-7-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine

: 871737-39-2
1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-fluorophenyl}-3-methyl-2-imidazolidinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 18 h / 130 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

3.1: tert.-butylnitrite; iodoform / tetrahydrofuran / 2.5 h / 20 °C / Heating / reflux

4.1: trifluoroacetic acid / dichloromethane / 3.5 h / 0 - 20 °C

5.1: acetic acid / dichloromethane / 0.5 h / 20 °C

5.2: 3 h / 20 °C

6.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 1 h / 140 °C

With copper(l) iodide; tert.-butylnitrite; iodoform; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane;

Reference yield:

: 720692-95-5
1,1-dimethylethyl 7-[(2-fluoro-4-nitrophenyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 871737-39-2
1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-fluorophenyl}-3-methyl-2-imidazolidinone

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

2.1: tert.-butylnitrite; iodoform / tetrahydrofuran / 2.5 h / 20 °C / Heating / reflux

3.1: trifluoroacetic acid / dichloromethane / 3.5 h / 0 - 20 °C

4.1: acetic acid / dichloromethane / 0.5 h / 20 °C

4.2: 3 h / 20 °C

5.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 1 h / 140 °C

With copper(l) iodide; tert.-butylnitrite; iodoform; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;