694-32-6

Basic information

• Product Name: 1-METHYL-2-IMIDAZOLIDINONE
• Synonyms: AKOS 25;1-METHYL-2-IMIDAZOLIDINONE;1-Methyl-2-imidazolidinone, 98+%;1-METHYLIMIDAZOLIDIN-2-ONE;1-Methyl-2-imidazilidinone;1-Methyl-2-iMidazolidinone, 98+% 500MG;1-Methyl-2-iMidazolidone;3-MethyliMidazolidin-2-one
• CAS NO: 694-32-6
• Molecular Formula: C₄H₈N₂O
• Molecular Weight: 100.12
• Product Categories: Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Chelating Agents & Ligands;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 694-32-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 122-123℃ (benzene )
• Boiling Point: 100-190℃ (13 Torr)
• Flash Point: 129.1 °C
• Appearance: Off-white to beige/Crystalline Solid
• Density: 1.1275 (rough estimate)
• Vapor Pressure: 0.00215mmHg at 25°C
• Refractive Index: 1.4880 (estimate)
• Storage Temp.: Indoors
• PKA: 14.39±0.20(Predicted)
• CAS DataBase Reference: 1-METHYL-2-IMIDAZOLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-2-IMIDAZOLIDINONE(694-32-6)
• EPA Substance Registry System: 1-METHYL-2-IMIDAZOLIDINONE(694-32-6)

Safety Data

• Hazard Codes: Xn,N
• Statements: 36/38-21/22-51/53-43-36-22
• Safety Statements: 36/37/39-26-61-36/37
• RIDADR: 2811
• Hazardous Substances Data: 694-32-6(Hazardous Substances Data)

Usage

Chemical Properties

off-white to beige crystalline solid

Uses

1-Methyl-2-imidazolidinone is an imidazole derivative used in the preparation of chelated carbene complexes as well as in bioactive compounds such as potent HIV integrase inhibitors active against raltegravir-resistant viruses.

InChI:InChI=1/C4H8N2O/c1-6-3-2-5-4(6)7/h2-3H2,1H3,(H,5,7)

Upstream product

• 67-56-1 methanol 
• 124-38-9 carbon dioxide 
• 107-15-3 ethylenediamine 
• 70-18-8 glutathion 
• 7218-04-4 N-Acetylcysteine 
• 53527-07-4 β-(4-hydroxyphenyl)ethyl iodoacetamide 
• 616-38-6 carbonic acid dimethyl ester 
• 164115-06-4 N-(2-chloroethyl)-N'-methyl-N'-[2-(D-alanyl-L-phenylalanyl-L-lysyl-amino)ethyl]-N-nitrosourea 
• 75697-81-3 1-methyl-2-phenacylthioimidazoline 
• 865-47-4 potassium tert-butylate 
• 75-65-0 tert-butyl alcohol 
• 87768-63-6 1N-paranitrophenoxycarbonyl-3N-methyl-2-imidazolidinone 

Downstream Products

• 882672-22-2 1-(2-amino-4-(trifluoromethyl)phenyl)-3-methylimidazolidin-2-one 
• 344903-55-5 N-vinyl-N'-methylimidazolidin-2-one 
• 1425970-99-5 tert-butyl 4-{4-[(3-methyl-2-oxoimidazolidin-1-yl)methyl]benzylidene}piperidine-1-carboxylate 
• 1427034-03-4 5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(3-methyl-2-oxoimidazolidin-1-yl)benzofuran-3-carboxamide 

Relevant articles and documents

Rational design of bifunctional catalyst from KF and ZnO combination on alumina for cyclic urea synthesis from CO2 and diamine

This study is mainly focused on the design of stable, active and selective catalyst for direct synthesis of 2-imidazolidinone (cyclic urea) from ethylenediamine and CO2. Based on the rationale for the catalyst properties needed for this reaction, KF, ZnO and Al2O3 combination was selected to design the catalyst. ZnO/KF/Al2O3 catalyst was prepared by stepwise wet-impregnation followed by the removal of physisorbed KF from the surface. High product yield could be achieved by tuning acid-base sites by varying the composition and calcination temperature. The catalysts were characterized by various techniques like XRD, N2-sorption, NH3-TPD, CO2-TPD, TEM, XPS and FT-IR measurements. It is shown that acidic and basic properties of the solvent can influence the activity and product selectivity for this reaction. Under optimized condition; 180 °C, 10 bar and 10 wt.% catalyst in batch mode, 96.3 % conversion and 89.6 % selectivity towards the 2-imidazolidinone were achieved.

Efficient and Green Preparation of 2-Imidazolidinone using Sulfamic Acid as Acidic Catalyst

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This work is dealing with basic hydrolysis in water of allophanic esters as possible models of carboxybiotin. A complex mechanism is involved likely due to competition of nucleophilic attack on the two carbonyl groups of the substrate. The rate of hydrolysis is significantly increased by metallic cation (Mg++), a specific effect which allows to consider characterization of selectivity of bond breaking between nitrogen and carboxylate group with other nucleophiles.