(5R,7S)-8-{[5-(benzyloxy)-4-isopropoxypyridin-2-yl]methyl}-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

Base Information

Chemical Name:(5R,7S)-8-{[5-(benzyloxy)-4-isopropoxypyridin-2-yl]methyl}-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide
CAS No.:1338821-45-6
Molecular Formula:C₃₀H₃₄FN₃O₄S
Molecular Weight:551.682
Hs Code.:

Synonyms:(5R,7S)-8-{[5-(benzyloxy)-4-isopropoxypyridin-2-yl]methyl}-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

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Chemical Property of (5R,7S)-8-{[5-(benzyloxy)-4-isopropoxypyridin-2-yl]methyl}-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

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Technology Process of (5R,7S)-8-{[5-(benzyloxy)-4-isopropoxypyridin-2-yl]methyl}-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

There total 13 articles about (5R,7S)-8-{[5-(benzyloxy)-4-isopropoxypyridin-2-yl]methyl}-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1338821-42-3
5-(benzyloxy)-2-(bromomethyl)-4-isopropoxypyridine

: 1338821-00-3
(5R,7S)-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

: 1338821-45-6
(5R,7S)-8-{[5-(benzyloxy)-4-isopropoxypyridin-2-yl]methyl}-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; for 18h;

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1338821-45-6
(5R,7S)-8-{[5-(benzyloxy)-4-isopropoxypyridin-2-yl]methyl}-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

Guidance literature:: Multi-step reaction with 10 steps

1: acetic acid / 18 h / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 19 h / 0 - 40 °C

3: sodium methylate; sodium hydrogencarbonate / methanol; ethyl acetate / 18 h / 20 °C

4: lithium hydroxide; water / tetrahydrofuran / 18 h / Reflux

5: hydrogenchloride; water / methanol / 0.5 h

6: sodium tetrahydroborate; methanol / 1 h / 20 °C

7: triethylamine / dichloromethane / 1 h / 0 °C

8: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 0 °C

9: hydrogenchloride / 1,4-dioxane; water / 3 h / Reflux

10: caesium carbonate / N,N-dimethyl-formamide / 18 h

With 2,6-dimethylpyridine; hydrogenchloride; methanol; sodium tetrahydroborate; water; sodium methylate; sodium hydrogencarbonate; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1193782-19-2
benzyl (2S,4R)-4-cyano-4-[(3-fluorophenyl)amino]-2-methyl-piperidine-1-carboxylate

: 1338821-45-6
(5R,7S)-8-{[5-(benzyloxy)-4-isopropoxypyridin-2-yl]methyl}-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

Guidance literature:: Multi-step reaction with 8 steps

1: 2,6-dimethylpyridine / dichloromethane / 19 h / 0 - 40 °C

2: lithium hydroxide; water / tetrahydrofuran / 18 h / Reflux

3: hydrogenchloride; water / methanol / 0.5 h

4: sodium tetrahydroborate; methanol / 1 h / 20 °C

5: triethylamine / dichloromethane / 1 h / 0 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 0 °C

7: hydrogenchloride / 1,4-dioxane; water / 3 h / Reflux

8: caesium carbonate / N,N-dimethyl-formamide / 18 h

With 2,6-dimethylpyridine; hydrogenchloride; methanol; sodium tetrahydroborate; water; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;