Technology Process of AcOH*H-TyrΨ(CH2O)Gly-Gly-Phe-Leu-NH2
There total 3 articles about AcOH*H-TyrΨ(CH2O)Gly-Gly-Phe-Leu-NH2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium formate;
palladium on activated charcoal;
In
methanol;
for 15h;
Ambient temperature;
DOI:10.1021/jm00112a018
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) N-methylmorpholine (NMM), isobutyl chloroformate (IBCF), 2.) NMM / 1.) DMF, -25 deg C, 5 min, 2.) DMF, -20 deg C
2: 98 percent / ammonium formate / 10percent Pd/C / methanol / 15 h / Ambient temperature
With
4-methyl-morpholine; ammonium formate; isobutyl chloroformate;
palladium on activated charcoal;
In
methanol;
DOI:10.1021/jm00112a018
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 76 percent / trifluoroacetic acid (TFA) / CH2Cl2 / 1 h / Ambient temperature
2: 1.) N-methylmorpholine (NMM), isobutyl chloroformate (IBCF), 2.) NMM / 1.) DMF, -25 deg C, 5 min, 2.) DMF, -20 deg C
3: 98 percent / ammonium formate / 10percent Pd/C / methanol / 15 h / Ambient temperature
With
4-methyl-morpholine; ammonium formate; trifluoroacetic acid; isobutyl chloroformate;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1021/jm00112a018
