(R)-tert-butyl (4-(4-(1-methyl-1H-imidazol-2-yl)-1H-1,2,3-triazol-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Base Information

• Chemical Name: (R)-tert-butyl (4-(4-(1-methyl-1H-imidazol-2-yl)-1H-1,2,3-triazol-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
• CAS No.: 1500076-17-4
• Molecular Formula: C₂₁H₂₅F₃N₆O₂
• Molecular Weight: 450.464
• Mol file: 1500076-17-4.mol

Synonyms:(R)-tert-butyl (4-(4-(1-methyl-1H-imidazol-2-yl)-1H-1,2,3-triazol-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Chemical Property of (R)-tert-butyl (4-(4-(1-methyl-1H-imidazol-2-yl)-1H-1,2,3-triazol-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl (4-(4-(1-methyl-1H-imidazol-2-yl)-1H-1,2,3-triazol-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

There total 4 articles about (R)-tert-butyl (4-(4-(1-methyl-1H-imidazol-2-yl)-1H-1,2,3-triazol-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(R)-tert-butyl (4-azido-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate (1500076-06-1) + 2-ethynyl-1-methyl-1H-imidazole (37067-93-9) → (R)-tert-butyl (4-(4-(1-methyl-1H-imidazol-2-yl)-1H-1,2,3-triazol-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate (1500076-17-4)

Guidance literature:

With copper(l) iodide; sodium L-ascorbate; In water; tert-butyl alcohol; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1002/cmdc.201300104

Reference yield:

(R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate (1048703-14-5) → (R)-tert-butyl (4-(4-(1-methyl-1H-imidazol-2-yl)-1H-1,2,3-triazol-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate (1500076-17-4)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.5 h / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 18 h / 67 °C

3: sodium L-ascorbate; copper(l) iodide / tert-butyl alcohol; water / 3 h / 80 °C / Inert atmosphere

With copper(l) iodide; sodium azide; sodium L-ascorbate; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1002/cmdc.201300104

Reference yield:

3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester (881995-73-9) → (R)-tert-butyl (4-(4-(1-methyl-1H-imidazol-2-yl)-1H-1,2,3-triazol-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate (1500076-17-4)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium borohydride / tetrahydrofuran / 2 h / 0 - 20 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C

3: sodium azide / N,N-dimethyl-formamide / 18 h / 67 °C

4: sodium L-ascorbate; copper(l) iodide / tert-butyl alcohol; water / 3 h / 80 °C / Inert atmosphere

With copper(l) iodide; lithium borohydride; sodium azide; sodium L-ascorbate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1002/cmdc.201300104

upstream raw materials:

(R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

(R)-tert-butyl (4-azido-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

2-ethynyl-1-methyl-1H-imidazole

Downstream raw materials:

(R)-4-(4-(1-methyl-1H-imidazol-2-yl)-1H-1,2,3-triazol-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride