1048703-14-5

Basic information

• Product Name: (R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
• Synonyms: (R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
• CAS NO: 1048703-14-5
• Molecular Weight: 319.324
• Mol File: 1048703-14-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate(1048703-14-5)
• EPA Substance Registry System: (R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate(1048703-14-5)

Safety Data

• Hazardous Substances Data: 1048703-14-5(Hazardous Substances Data)

Upstream product

• 1380298-43-0 C₁₇H₂₇NO₆S 
• 327-52-6 1-bromo-2,4,5-trifluorobenzene 
• 191655-46-6 tert-butyl (S)-(4-((tert-butyldimethylsilyl)oxy)-1-hydroxybutan-2-yl)carbamate 
• 59408-74-1 (S)-2-((tert-butoxy)carbonylamino)-4-(phenylmethoxy)butyric acid 
• 247093-36-3 (S)-2-(tert-butoxycarbonylamino)-4-(methylthio)butyl methanesulfonate 
• 1380243-18-4 C₁₀H₁₉NO₂S 
• 1380243-23-1 (S)-tert-butyl 2-(2-(tert-butyldimethylsilyloxy)ethyl)aziridine-1-carboxylate 
• 1380243-24-2 C₁₁H₂₁NO₄ 
• 1380243-25-3 C₁₆H₂₃NO₃ 
• 1380243-28-6 C₁₆H₂₂F₃NO₂S 
• 1380243-35-5 (R)-tert-butyl 4-(tert-butyldimethylsilyloxy)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 1380243-37-7 C₁₇H₂₄F₃NO₄ 
• 1380243-39-9 C₂₂H₂₆F₃NO₃ 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1048703-15-6 tert-butyl (R)-(4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate 
• 1500076-58-3 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)benzamide hydrochloride 
• 1500076-59-4 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)-2,3-difluorobenzamide hydrochloride 
• 1500076-60-7 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)-4-methoxybenzamide hydrochloride 
• 1500076-61-8 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)-4-(methylsulfonyl)-benzamide hydrochloride 
• 1500076-62-9 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)-4-sulfamoylbenzamide hydrochloride 
• 1500076-63-0 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)-4-(trifluoromethyl)benzamide hydrochloride 
• 1500076-64-1 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)-4-(1H-1,2,4-triazol-1-yl)benzamidehydrochloride 
• 1500076-65-2 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)-1H-benzo[d]imidazole-6-carboxamide hydrochloride 
• 1500076-66-3 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)-1H-benzo[d]-[1,2,3]triazole-6-carboxamide hydrochloride 
• 1500076-67-4 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)nicotinamide hydrochloride 
• 1500076-68-5 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)thiophene-3-carboxamide hydrochloride 
• 1500076-69-6 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)quinoline-6-carboxamide hydrochloride 
• 1500076-70-9 (R)-N-(3-amino-4-(2,4,5-trifluorophenyl)butyl)-2-phenylacetamide hydrochloride 

Relevant articles and documents

Practical asymmetric synthesis of Sitagliptin phosphate monohydrate

Optically pure sitagliptin phosphate monohydrate is efficiently and practically synthesized through a chiral hemiacetal as the key intermediate in 54% overall yield starting from (E)-4-(2,4,5-trifluorophenyl)but-2-enal and N-boc-protected hydroxylamine. The chiral hemiacetal fragment is constructed by a tandem aza-Michael/hemiacetal reaction catalyzed by an organocatalyst and the influence of acidity of Br?nsted acid on tandem aza-Michael/hemiacetal reaction is researched in detail.

INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF

Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.

INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF

Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.