3-Fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-1,3-thiazol-2-ylbenzenesulfonamide

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Chemical Name:3-Fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-1,3-thiazol-2-ylbenzenesulfonamide
CAS No.:1354786-14-3
Molecular Formula:C₂₅H₁₉FN₄O₃S₂
Molecular Weight:506.581
Hs Code.:

Synonyms:3-Fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-1,3-thiazol-2-ylbenzenesulfonamide

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Chemical Property of 3-Fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-1,3-thiazol-2-ylbenzenesulfonamide

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Technology Process of 3-Fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-1,3-thiazol-2-ylbenzenesulfonamide

There total 6 articles about 3-Fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-1,3-thiazol-2-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 96-50-4
2-thiazolylamine

: 1354786-78-9
3-fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonyl chloride

: 1354786-14-3
3-Fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-1,3-thiazol-2-ylbenzenesulfonamide

Guidance literature:: With pyridine; at 20 ℃; for 12h;

Reference yield:

: 114250-18-9
2-bromo-1-(phenylmethoxy)-4-phenylbenzene

: 1354786-14-3
3-Fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-1,3-thiazol-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dipotassium hydrogenphosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / methanol / 16 h

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 16 h / 20 °C

4.1: water; calcium chloride; iron / ethanol / 3 h / Reflux

5.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0.5 h / 0 °C

5.2: 0 - 20 °C

6.1: pyridine / 12 h / 20 °C

With pyridine; hydrogenchloride; dipotassium hydrogenphosphate; water; hydrogen; iron; potassium carbonate; acetic acid; calcium chloride; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; tricyclohexylphosphine; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; 1.1: Suzuki Coupling;

Reference yield:

: 1354786-74-5
5-[4-(benzyloxy)biphenyl-3-yl]-1-methyl-1H-pyrazole

: 1354786-14-3
3-Fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}-N-1,3-thiazol-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium on activated charcoal / methanol / 16 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 16 h / 20 °C

3.1: water; calcium chloride; iron / ethanol / 3 h / Reflux

4.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0.5 h / 0 °C

4.2: 0 - 20 °C

5.1: pyridine / 12 h / 20 °C

With pyridine; hydrogenchloride; water; hydrogen; iron; potassium carbonate; acetic acid; calcium chloride; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; water; N,N-dimethyl-formamide;