3-fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonyl chloride

Base Information

Chemical Name:3-fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonyl chloride
CAS No.:1354786-78-9
Molecular Formula:C₂₂H₁₆ClFN₂O₃S
Molecular Weight:442.898
Hs Code.:

Synonyms:3-fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonyl chloride

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Chemical Property of 3-fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonyl chloride

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Technology Process of 3-fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonyl chloride

There total 5 articles about 3-fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1354786-77-8
3-fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}aniline

: 1354786-78-9
3-fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonyl chloride

Guidance literature:: 3-fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}aniline; With hydrogenchloride; acetic acid; sodium nitrite; In water; at 0 ℃; for 0.5h;

With copper(II) choride dihydrate; sulfur dioxide; In water; at 0 - 20 ℃;

Reference yield:

: 1354786-74-5
5-[4-(benzyloxy)biphenyl-3-yl]-1-methyl-1H-pyrazole

: 1354786-78-9
3-fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium on activated charcoal / methanol / 16 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 16 h / 20 °C

3.1: water; calcium chloride; iron / ethanol / 3 h / Reflux

4.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0.5 h / 0 °C

4.2: 0 - 20 °C

With hydrogenchloride; water; hydrogen; iron; potassium carbonate; acetic acid; calcium chloride; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 114250-18-9
2-bromo-1-(phenylmethoxy)-4-phenylbenzene

: 1354786-78-9
3-fluoro-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: dipotassium hydrogenphosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / methanol / 16 h

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 16 h / 20 °C

4.1: water; calcium chloride; iron / ethanol / 3 h / Reflux

5.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0.5 h / 0 °C

5.2: 0 - 20 °C

With hydrogenchloride; dipotassium hydrogenphosphate; water; hydrogen; iron; potassium carbonate; acetic acid; calcium chloride; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; tricyclohexylphosphine; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; 1.1: Suzuki Coupling;