4-(3-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)propyl)-2-methoxyphenol

Base Information

Chemical Name:4-(3-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)propyl)-2-methoxyphenol
CAS No.:1612146-60-7
Molecular Formula:C₂₀H₂₉N₃O₂S
Molecular Weight:375.535
Hs Code.:

Synonyms:4-(3-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)propyl)-2-methoxyphenol

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Chemical Property of 4-(3-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)propyl)-2-methoxyphenol

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Technology Process of 4-(3-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)propyl)-2-methoxyphenol

There total 4 articles about 4-(3-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)propyl)-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 104617-86-9
2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole

: 80638-48-8
3-(3'-methoxy-4'-hydroxyphenyl)propionaldehyde

: 1612146-60-7
4-(3-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)propyl)-2-methoxyphenol

Guidance literature:: 2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole; 3-(3'-methoxy-4'-hydroxyphenyl)propionaldehyde; In dichloromethane; for 1h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In methanol; dichloromethane; at 20 ℃; for 36h; Inert atmosphere;
DOI:10.1016/j.bmc.2016.08.021

Reference yield: 46.0%

: 1612146-60-7
4-(3-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)propyl)-2-methoxyphenol

Guidance literature:: In dichloromethane; for 1h;

With sodium tris(acetoxy)borohydride; In methanol; dichloromethane; at 20 ℃; for 36h; Solvent;

Reference yield:

: 61292-90-8
ethyl 3-(4-hydroxy-3-methoxyphenyl)propanoate

: 1612146-60-7
4-(3-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)propyl)-2-methoxyphenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / toluene; hexane / 2 h / -78 °C / Inert atmosphere

2.1: dichloromethane / 1 h / Inert atmosphere

2.2: 36 h / 20 °C / Inert atmosphere

With diisobutylaluminium hydride; In hexane; dichloromethane; toluene;
DOI:10.1016/j.bmc.2016.08.021