methyl 4-(2-amino-5-chlorophenyl)-4-oxobutyrate

Base Information

• Chemical Name: methyl 4-(2-amino-5-chlorophenyl)-4-oxobutyrate
• CAS No.: 80452-54-6
• Molecular Formula: C₁₁H₁₂ClNO₃
• Molecular Weight: 241.674
• Mol file: 80452-54-6.mol

Synonyms:methyl 4-(2-amino-5-chlorophenyl)-4-oxobutyrate

Chemical Property of methyl 4-(2-amino-5-chlorophenyl)-4-oxobutyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(2-amino-5-chlorophenyl)-4-oxobutyrate

There total 6 articles about methyl 4-(2-amino-5-chlorophenyl)-4-oxobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C11H10ClNO5 (1417520-48-9) → methyl 4-(2-amino-5-chlorophenyl)-4-oxobutyrate (80452-54-6)

Guidance literature:

With 1% platinum on charcoal; hydrogen; In ethanol;

DOI:10.1016/j.cclet.2012.11.001

Reference yield:

C10H8ClNO5 (1428426-19-0) → methyl 4-(2-amino-5-chlorophenyl)-4-oxobutyrate (80452-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: hydrogen; 1% platinum on charcoal / ethanol

With sulfuric acid; 1% platinum on charcoal; hydrogen; In ethanol;

DOI:10.1016/j.cclet.2012.11.001

Reference yield:

4-(3-chlorophenyl)-4-oxobutyric acid (62903-14-4) → methyl 4-(2-amino-5-chlorophenyl)-4-oxobutyrate (80452-54-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / -20 °C

2: sulfuric acid / Reflux

3: hydrogen; 1% platinum on charcoal / ethanol

With sulfuric acid; 1% platinum on charcoal; hydrogen; nitric acid; In ethanol;

DOI:10.1016/j.cclet.2012.11.001

upstream raw materials:

ethyl 5-chloro-3-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylate

4-(3-chlorophenyl)-4-oxobutyric acid

C₁₀H₈ClNO₅

C₁₁H₁₀ClNO₅

Downstream raw materials:

C₁₉H₁₉ClN₂O₄

C₂₇H₂₅ClN₂O₅

DM-4103

DM-4107

Refernces

• 1、 Rossi, Silvano,Micheli, Marcello,Giannotti, Michele,Salvatori, Americo,Peruzzi, Guidubaldo. "BENZOCONDENSED HEPTAATOMIC HETEROCYCLES AND THEIR DERIVATIVES. VII. SYNTHESIS OF BENZAZEPINES AND BENZAZEPINONES ANALOGUES OF KNOWN ANXIOLYTIC DRUGS". . p. 365 - 370. Retrieved 2007/10/02.