2-difluoromethyl-4-azidophenyl 5-acetoamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid

Base Information

Chemical Name:2-difluoromethyl-4-azidophenyl 5-acetoamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid
CAS No.:1374114-52-9
Molecular Formula:C₁₈H₂₂F₂N₄O₉
Molecular Weight:476.391
Hs Code.:

Synonyms:2-difluoromethyl-4-azidophenyl 5-acetoamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid

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Chemical Property of 2-difluoromethyl-4-azidophenyl 5-acetoamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid

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Technology Process of 2-difluoromethyl-4-azidophenyl 5-acetoamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid

There total 7 articles about 2-difluoromethyl-4-azidophenyl 5-acetoamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₄F₂N₄O₉

: 1374114-52-9
2-difluoromethyl-4-azidophenyl 5-acetoamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid

Guidance literature:: C₁₉H₂₄F₂N₄O₉; With sodium hydroxide; In water; at 20 ℃; for 1h;

With acetic acid; In water; at 20 ℃;
DOI:10.1016/j.bmc.2012.02.001

Reference yield:

: 1374114-54-1
C₂₇H₃₂N₄O₁₄

: 1374114-52-9
2-difluoromethyl-4-azidophenyl 5-acetoamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 2 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: sodium hydroxide / water / 1 h / 20 °C

3.2: 20 °C

With diethylamino-sulfur trifluoride; sodium methylate; sodium hydroxide; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2012.02.001

Reference yield:

: 97-51-8
5-Nitrosalicylaldehyde

: 1374114-52-9
2-difluoromethyl-4-azidophenyl 5-acetoamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: acetic acid; zinc / 1 h / 20 °C

3.1: acetic acid; sodium nitrite / water / 2 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: 36 h / 20 °C / Inert atmosphere; Neat (no solvent)

4.2: 24 h / 20 °C / Inert atmosphere

5.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / 20 °C / Inert atmosphere

6.1: sodium methylate / methanol / 2 h / 20 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

7.1: sodium hydroxide / water / 1 h / 20 °C

7.2: 20 °C

With diethylamino-sulfur trifluoride; boron trifluoride diethyl etherate; sodium methylate; acetic acid; sodium hydroxide; zinc; sodium nitrite; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2012.02.001