2-[(5-cyano-4-(4-hydroxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

Base Information

Chemical Name:2-[(5-cyano-4-(4-hydroxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide
CAS No.:1382228-90-1
Molecular Formula:C₂₉H₂₀Cl₂N₆O₅S
Molecular Weight:635.487
Hs Code.:

2-[(5-cyano-4-(4-hydroxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

Synonyms:2-[(5-cyano-4-(4-hydroxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

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Chemical Property of 2-[(5-cyano-4-(4-hydroxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

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Technology Process of 2-[(5-cyano-4-(4-hydroxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

There total 6 articles about 2-[(5-cyano-4-(4-hydroxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1382228-58-1
2-[(5-cyano-4-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

: 74-88-4
methyl iodide

: 1382228-90-1
2-[(5-cyano-4-(4-hydroxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

Guidance literature:: With potassium carbonate; In ethanol; for 8h; Reflux;
DOI:10.1016/j.ejmech.2012.03.050

Reference yield:

: 1150095-03-6
2-chloro-N-(2-(2,4-dichlorophenoxymethyl)-4-oxo-quinazolin-3(4H)-yl)acetamide

: 1382228-90-1
2-[(5-cyano-4-(4-hydroxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 6 h / Reflux

2: potassium carbonate / ethanol / 8 h / Reflux

With potassium carbonate; In ethanol; acetone;
DOI:10.1016/j.ejmech.2012.03.050

Reference yield:

: 303794-61-8
2-[2-(2,4-dichlorophenoxy)acetylamino]benzoic acid methyl ester

: 1382228-90-1
2-[(5-cyano-4-(4-hydroxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / butan-1-ol / 10 h / Reflux

2: triethylamine / benzene / 4 h / Reflux

3: potassium carbonate / acetone / 6 h / Reflux

4: potassium carbonate / ethanol / 8 h / Reflux

With potassium carbonate; hydrazine hydrate; triethylamine; In ethanol; acetone; butan-1-ol; benzene;
DOI:10.1016/j.ejmech.2012.03.050