6-{[2,6-dichloro-4-(2,2-difluoro-1-hydroxy-1-methoxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

Base Information

Chemical Name:6-{[2,6-dichloro-4-(2,2-difluoro-1-hydroxy-1-methoxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one
CAS No.:1131736-98-5
Molecular Formula:C₂₀H₁₄Cl₂F₂N₄O₃
Molecular Weight:467.259
Hs Code.:

Synonyms:6-{[2,6-dichloro-4-(2,2-difluoro-1-hydroxy-1-methoxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

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Chemical Property of 6-{[2,6-dichloro-4-(2,2-difluoro-1-hydroxy-1-methoxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

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Technology Process of 6-{[2,6-dichloro-4-(2,2-difluoro-1-hydroxy-1-methoxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

There total 9 articles about 6-{[2,6-dichloro-4-(2,2-difluoro-1-hydroxy-1-methoxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1131736-94-1
N-(2,6-dichloro-4-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]vinyl}phenyl)-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

: 1131736-95-2
N-(2,6-dichloro-4-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]vinyl}phenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

: 1131736-96-3
6-{[2,6-dichloro-4-(difluoroacetyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

: 1131736-98-5
6-{[2,6-dichloro-4-(2,2-difluoro-1-hydroxy-1-methoxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

: 1131736-97-4
6-{[2,6-dichloro-4-(2,2-difluoro-1,1-dihydroxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

Guidance literature:: With boron tribromide; In dichloromethane; chloroform; at 85 ℃; for 0.666667h;

Reference yield:

: 1131736-67-8
N-(2,6-dichloro-4-iodophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

: C₆H₉BF₅O₃^(1-)

: 1131736-96-3
6-{[2,6-dichloro-4-(difluoroacetyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

: 1131736-98-5
6-{[2,6-dichloro-4-(2,2-difluoro-1-hydroxy-1-methoxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

: 1610056-89-7
C₂₁H₁₆Cl₂F₂N₄O₃

Guidance literature:: N-(2,6-dichloro-4-iodophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine; C₆H₉BF₅O₃^(1-); With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In propan-1-ol; at 90 ℃;

With boron tribromide; In chloroform; at 85 ℃;
DOI:10.1016/j.bmcl.2014.02.011

Reference yield:

: 1131736-51-0
10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-ol

: 1131736-96-3
6-{[2,6-dichloro-4-(difluoroacetyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

: 1131736-98-5
6-{[2,6-dichloro-4-(2,2-difluoro-1-hydroxy-1-methoxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

: 1610056-89-7
C₂₁H₁₆Cl₂F₂N₄O₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 100 °C / Microwave irradiation

2.1: sodium t-butanolate / tetrahydrofuran / 85 °C

3.1: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / propan-1-ol / 90 °C

3.2: 85 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; propan-1-ol;
DOI:10.1016/j.bmcl.2014.02.011