N-(2,6-dichloro-4-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]vinyl}phenyl)-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Base Information

• Chemical Name: N-(2,6-dichloro-4-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]vinyl}phenyl)-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine
• CAS No.: 1131736-94-1
• Molecular Formula: C₂₄H₂₀Cl₂F₂N₄O₄
• Molecular Weight: 537.35

Synonyms:N-(2,6-dichloro-4-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]vinyl}phenyl)-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Chemical Property of N-(2,6-dichloro-4-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]vinyl}phenyl)-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Chemical Property:

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Technology Process of N-(2,6-dichloro-4-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]vinyl}phenyl)-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

There total 1 articles about N-(2,6-dichloro-4-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]vinyl}phenyl)-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2,6-dichloro-4-iodophenyl)-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (1131736-69-0) + N-(2,6-dichloro-4-iodophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (1131736-67-8) + potassium 2,2-difluoro-1-(2-methoxy-ethoxymethoxy)ethenyltrifluoroborate → N-(2,6-dichloro-4-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]vinyl}phenyl)-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (1131736-94-1) + N-(2,6-dichloro-4-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]vinyl}phenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (1131736-95-2)

Guidance literature:

With triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In propan-1-ol; at 90 ℃;

Reference yield:

N-(2,6-dichloro-4-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]vinyl}phenyl)-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (1131736-94-1) + N-(2,6-dichloro-4-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]vinyl}phenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (1131736-95-2) → 6-{[2,6-dichloro-4-(difluoroacetyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one (1131736-96-3) + 6-{[2,6-dichloro-4-(2,2-difluoro-1-hydroxy-1-methoxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one (1131736-98-5) + 6-{[2,6-dichloro-4-(2,2-difluoro-1,1-dihydroxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one (1131736-97-4)

Guidance literature:

With boron tribromide; In dichloromethane; chloroform; at 85 ℃; for 0.666667h;

upstream raw materials:

N-(2,6-dichloro-4-iodophenyl)-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

N-(2,6-dichloro-4-iodophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Downstream raw materials:

6-{[2,6-dichloro-4-(difluoroacetyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

6-{[2,6-dichloro-4-(2,2-difluoro-1-hydroxy-1-methoxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

6-{[2,6-dichloro-4-(2,2-difluoro-1,1-dihydroxyethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

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