(S)-5-Hydroxy-4-(2-methoxy-4-methyl-phenyl)-pentanoic acid methyl ester

Base Information

• Chemical Name: (S)-5-Hydroxy-4-(2-methoxy-4-methyl-phenyl)-pentanoic acid methyl ester
• CAS No.: 170423-70-8
• Molecular Formula: C₁₄H₂₀O₄
• Molecular Weight: 252.31
• Mol file: 170423-70-8.mol

Synonyms:(S)-5-Hydroxy-4-(2-methoxy-4-methyl-phenyl)-pentanoic acid methyl ester

Chemical Property of (S)-5-Hydroxy-4-(2-methoxy-4-methyl-phenyl)-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5-Hydroxy-4-(2-methoxy-4-methyl-phenyl)-pentanoic acid methyl ester

There total 4 articles about (S)-5-Hydroxy-4-(2-methoxy-4-methyl-phenyl)-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (4S)-(2-methoxy-4-methylpenyl)-5-hydroxypentanoate (170423-66-2) → (S)-5-Hydroxy-4-(2-methoxy-4-methyl-phenyl)-pentanoic acid methyl ester (170423-70-8)

Guidance literature:

With hydrogen; palladium dihydroxide;

DOI:10.1016/0957-4166(95)00229-I

Reference yield:

(E)-5-Acetoxy-4-(2-methoxy-4-methyl-phenyl)-pent-2-enoic acid methyl ester (164921-78-2) → (S)-5-Hydroxy-4-(2-methoxy-4-methyl-phenyl)-pentanoic acid methyl ester (170423-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: immobilized lipase (MY-30); H₂O / diisopropyl ether / 72 h / 33 °C

2: H₂ / 20 percent Pd(OH)2-C / ethyl acetate / 20 °C

With immobilized lipase (MY-30); water; hydrogen; palladium hydroxide - carbon; In di-isopropyl ether; ethyl acetate;

DOI:10.1248/cpb.49.1581

Reference yield:

methyl 4-(2'-methoxy-4'-methylphenyl)-5-hydroxy-(2E)-pentanoate (164921-74-8) → (S)-5-Hydroxy-4-(2-methoxy-4-methyl-phenyl)-pentanoic acid methyl ester (170423-70-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: H₂O / diisopropyl ether / immobilized lipase MY-30 from Candida cylindracea

3: H₂ / Pd(OH)2/C

With pyridine; water; hydrogen; palladium dihydroxide; In di-isopropyl ether;

DOI:10.1016/0957-4166(95)00229-I

upstream raw materials:

methyl (4S)-(2-methoxy-4-methylpenyl)-5-hydroxypentanoate

(E)-5-Acetoxy-4-(2-methoxy-4-methyl-phenyl)-pent-2-enoic acid methyl ester

methyl 4-(2'-methoxy-4'-methylphenyl)-5-hydroxy-(2E)-pentanoate

(E)-(S)-5-Acetoxy-4-(2-methoxy-4-methyl-phenyl)-pent-2-enoic acid methyl ester

Downstream raw materials:

methyl (4S)-(2-methoxy-4-methylphenyl)-5-tosyloxypentanoate

(S)-4-(4-Methyl-2-trifluoromethanesulfonyloxy-phenyl)-pentanoic acid methyl ester

methyl-(5S)-(2-methoxy-4-methylphenyl)hexanoate

(S)-5-(2-Hydroxy-4-methyl-phenyl)-hexanoic acid methyl ester