1-(tert-butyl)-3-((2S,3R)-4-((R)-7-fluoro-4-isopropyl-1,1-dioxido-4,5-dihydrobenzo[1,2-f]thiazepin-2(3H)-yl)-3-hydroxy-1-phenylbutan-2-yl)urea

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Chemical Name:1-(tert-butyl)-3-((2S,3R)-4-((R)-7-fluoro-4-isopropyl-1,1-dioxido-4,5-dihydrobenzo[1,2-f]thiazepin-2(3H)-yl)-3-hydroxy-1-phenylbutan-2-yl)urea
CAS No.:1601490-35-0
Molecular Formula:C₂₇H₃₈FN₃O₄S
Molecular Weight:519.681
Hs Code.:

Synonyms:1-(tert-butyl)-3-((2S,3R)-4-((R)-7-fluoro-4-isopropyl-1,1-dioxido-4,5-dihydrobenzo[1,2-f]thiazepin-2(3H)-yl)-3-hydroxy-1-phenylbutan-2-yl)urea

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Chemical Property of 1-(tert-butyl)-3-((2S,3R)-4-((R)-7-fluoro-4-isopropyl-1,1-dioxido-4,5-dihydrobenzo[1,2-f]thiazepin-2(3H)-yl)-3-hydroxy-1-phenylbutan-2-yl)urea

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Technology Process of 1-(tert-butyl)-3-((2S,3R)-4-((R)-7-fluoro-4-isopropyl-1,1-dioxido-4,5-dihydrobenzo[1,2-f]thiazepin-2(3H)-yl)-3-hydroxy-1-phenylbutan-2-yl)urea

There total 11 articles about 1-(tert-butyl)-3-((2S,3R)-4-((R)-7-fluoro-4-isopropyl-1,1-dioxido-4,5-dihydrobenzo[1,2-f]thiazepin-2(3H)-yl)-3-hydroxy-1-phenylbutan-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1601490-29-2
(R)-2-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-7-fluoro-4-isopropyl-2,3,4,5-tetrahydrobenzo[1,2-f]thiazepine 1,1-dioxide

: 1609-86-5
Tert-butyl isocyanate

: 1601490-35-0
1-(tert-butyl)-3-((2S,3R)-4-((R)-7-fluoro-4-isopropyl-1,1-dioxido-4,5-dihydrobenzo[1,2-f]thiazepin-2(3H)-yl)-3-hydroxy-1-phenylbutan-2-yl)urea

Guidance literature:: With magnesium bromide; In 1,4-dioxane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2014.03.038

Reference yield:

: 351003-45-7
2-bromo-4-fluorobenzene-1-sulfonyl chloride

: 1601490-35-0
1-(tert-butyl)-3-((2S,3R)-4-((R)-7-fluoro-4-isopropyl-1,1-dioxido-4,5-dihydrobenzo[1,2-f]thiazepin-2(3H)-yl)-3-hydroxy-1-phenylbutan-2-yl)urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / dichloromethane / 20 °C / Inert atmosphere

2.1: sodium iodide; caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: ammonium cerium (IV) nitrate / acetonitrile; water / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / Inert atmosphere; Reflux

5.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

7.1: magnesium bromide / 1,4-dioxane / 20 °C / Inert atmosphere

With pyridine; ammonium cerium (IV) nitrate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; caesium carbonate; trifluoroacetic acid; sodium iodide; magnesium bromide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.tet.2014.03.038

Reference yield:

: 26903-66-2
2-isopropylallyl alcohol

: 1601490-35-0
1-(tert-butyl)-3-((2S,3R)-4-((R)-7-fluoro-4-isopropyl-1,1-dioxido-4,5-dihydrobenzo[1,2-f]thiazepin-2(3H)-yl)-3-hydroxy-1-phenylbutan-2-yl)urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphorus tribromide / diethyl ether / 0 - 20 °C / Inert atmosphere

2.1: sodium iodide; caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: ammonium cerium (IV) nitrate / acetonitrile; water / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / Inert atmosphere; Reflux

5.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

7.1: magnesium bromide / 1,4-dioxane / 20 °C / Inert atmosphere

With ammonium cerium (IV) nitrate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; phosphorus tribromide; caesium carbonate; trifluoroacetic acid; sodium iodide; magnesium bromide; In 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.tet.2014.03.038