2-trifluoromethylsulphonyloxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methoxybenzaldehyde

Base Information

Chemical Name:2-trifluoromethylsulphonyloxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methoxybenzaldehyde
CAS No.:163117-73-5
Molecular Formula:C₂₃H₂₅F₃O₅S
Molecular Weight:470.51
Hs Code.:

Synonyms:2-trifluoromethylsulphonyloxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methoxybenzaldehyde

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Chemical Property of 2-trifluoromethylsulphonyloxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methoxybenzaldehyde

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Technology Process of 2-trifluoromethylsulphonyloxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methoxybenzaldehyde

There total 3 articles about 2-trifluoromethylsulphonyloxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 407-25-0
trifluoroacetic anhydride

: 163117-72-4
3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methoxy-salicylaldehyde

: 163117-73-5
2-trifluoromethylsulphonyloxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methoxybenzaldehyde

Guidance literature:: With dmap; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/S0968-0896(00)00047-X

Reference yield:

: 24677-78-9
2,3-dihydroxybenzaldehyde

: 163117-73-5
2-trifluoromethylsulphonyloxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methoxybenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride; DMSO / 1 h / 20 °C

1.2: 44 percent / dimethylsulfoxide / 20 °C

2.1: 47 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h / 0 °C

With dmap; sodium hydride; dimethyl sulfoxide; In dichloromethane; 1.1: deprotonation / 1.2: Substitution / 2.1: trifluoromethylsulphonylation;
DOI:10.1016/S0968-0896(00)00047-X

Reference yield:

: 163117-71-3
6-chloromethyl-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene

: 163117-73-5
2-trifluoromethylsulphonyloxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methoxybenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride; DMSO / 1 h / 20 °C

1.2: 44 percent / dimethylsulfoxide / 20 °C

2.1: 47 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h / 0 °C

With dmap; sodium hydride; dimethyl sulfoxide; In dichloromethane; 1.1: deprotonation / 1.2: Substitution / 2.1: trifluoromethylsulphonylation;
DOI:10.1016/S0968-0896(00)00047-X