1-benzyl 4-methyl (S)-3-((tert-butoxycarbonyl)amino)-2,2-dimethylsuccinate

Base Information

Chemical Name:1-benzyl 4-methyl (S)-3-((tert-butoxycarbonyl)amino)-2,2-dimethylsuccinate
CAS No.:1449476-12-3
Molecular Formula:C₁₉H₂₇NO₆
Molecular Weight:365.426
Hs Code.:

Synonyms:1-benzyl 4-methyl (S)-3-((tert-butoxycarbonyl)amino)-2,2-dimethylsuccinate

Suppliers and Price of 1-benzyl 4-methyl (S)-3-((tert-butoxycarbonyl)amino)-2,2-dimethylsuccinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-benzyl 4-methyl (S)-3-((tert-butoxycarbonyl)amino)-2,2-dimethylsuccinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-benzyl 4-methyl (S)-3-((tert-butoxycarbonyl)amino)-2,2-dimethylsuccinate

There total 4 articles about 1-benzyl 4-methyl (S)-3-((tert-butoxycarbonyl)amino)-2,2-dimethylsuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 158201-15-1
α-benzyl β-methyl N^α-tert-butoxycarbonyl-(S)-aspartate

: 74-88-4
methyl iodide

: 1449476-12-3
1-benzyl 4-methyl (S)-3-((tert-butoxycarbonyl)amino)-2,2-dimethylsuccinate

Guidance literature:: α-benzyl β-methyl N^α-tert-butoxycarbonyl-(S)-aspartate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃; for 19h;

Reference yield:

: 74-88-4
methyl iodide

: 1014697-33-6
C₁₈H₂₅NO₆

: 1449476-12-3
1-benzyl 4-methyl (S)-3-((tert-butoxycarbonyl)amino)-2,2-dimethylsuccinate

Guidance literature:: 4-benzyl 1-methyl N-(tert-butoxycarbonyl)-L-aspartate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at -78 ℃; for 6h;

Reference yield:

: 80963-12-8
4-benzyl 1-methyl N-(tert-butoxycarbonyl)-L-aspartate

: 74-88-4
methyl iodide

: 1449476-12-3
1-benzyl 4-methyl (S)-3-((tert-butoxycarbonyl)amino)-2,2-dimethylsuccinate

Guidance literature:: 4-benzyl 1-methyl N-(tert-butoxycarbonyl)-L-aspartate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2018.12.002