methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Base Information

Chemical Name:methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate
CAS No.:1034774-69-0
Molecular Formula:C₃₃H₄₃N₃O₅
Molecular Weight:561.722
Hs Code.:

Synonyms:methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Suppliers and Price of methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

There total 16 articles about methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl (7R)-14-cyclohexyl-7-(methylamino)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate: 1034774-68-9
methyl (7R)-14-cyclohexyl-7-(methylamino)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

: 89711-08-0
N-(t-butoxycarbonyl)glycinal

methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate: 1034774-69-0
methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: methyl (7R)-14-cyclohexyl-7-(methylamino)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate; N-(t-butoxycarbonyl)glycinal; With sodium acetate; acetic acid; In methanol; at 20 ℃; for 0.25h;

With hydrogen; palladium on activated charcoal; In methanol; at 60 ℃;

Reference yield:

: 886041-53-8
3-cyclohexyl-2-{2-[(2S)-oxiran-2-ylmethoxy]phenyl}-1H-indole-6-carboxylic acid methyl ester

methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate: 1034774-69-0
methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / 1,4-dioxane / 100 °C

2.1: pyridine

3.1: trimethylsilylazide; tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 70 °C

4.1: palladium on carbon; hydrogen / methanol

5.1: tetrahydrofuran / 20 °C

6.1: dimethylsulfide borane complex / tetrahydrofuran / 20 h / 20 °C

6.2: 2 h / Heating

7.1: sodium acetate; acetic acid / methanol / 0.25 h / 20 °C

8.1: palladium on carbon; hydrogen / methanol / Heating

With pyridine; trimethylsilylazide; dimethylsulfide borane complex; palladium on carbon; hydrogen; sodium acetate; caesium carbonate; acetic acid; tetrabutylammonium triphenyldifluorosilicate; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1055/s-0030-1260790

Reference yield:

: 863578-50-1
3-cyclohexyl-2-(2-hydroxy-phenyl)-1H-indole-6-carboxylic acid methyl ester

methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate: 1034774-69-0
methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: cesium fluoride / N,N-dimethyl-formamide

2.1: caesium carbonate / 1,4-dioxane / 100 °C

3.1: pyridine

4.1: trimethylsilylazide; tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 70 °C

5.1: palladium on carbon; hydrogen / methanol

6.1: tetrahydrofuran / 20 °C

7.1: dimethylsulfide borane complex / tetrahydrofuran / 20 h / 20 °C

7.2: 2 h / Heating

8.1: sodium acetate; acetic acid / methanol / 0.25 h / 20 °C

9.1: palladium on carbon; hydrogen / methanol / Heating

With pyridine; trimethylsilylazide; dimethylsulfide borane complex; palladium on carbon; hydrogen; sodium acetate; caesium carbonate; acetic acid; cesium fluoride; tetrabutylammonium triphenyldifluorosilicate; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1055/s-0030-1260790