886041-53-8Relevant articles and documents
Mitsunobu inversion of a secondary alcohol with diphenylphosphoryl azide. application to the enantioselective multikilogram synthesis of a HCV polymerase inhibitor
Scott, Jeremy P.,Alam, Mahbub,Bremeyer, Nadine,Goodyear, Adrian,Wilson, Robert D.,Lam, Thientu,Zhou, George
experimental part, p. 1116 - 1123 (2012/01/03)
The development of a practical synthesis of the hepatitis C virus polymerase inhibitor 1 was necessary to support preclinical safety and human clinical studies. Significant challenges face the process chemist in developing a route to 1 that is amenable to
Development of a scalable chiral synthesis of MK-3281, an inhibitor of the hepatitis C virus NS5B polymerase
Colarusso, Stefania,Conte, Immacolata,Di Filippo, Marcello,Ercolani, Caterina,MacKay, Angela C.,Palumbi, Maria Cecilia,Rico Ferreira, Maria Del Rosario,Stansfield, Ian,Zaramella, Simone,Narjes, Frank,Habermann, J?rg
scheme or table, p. 1527 - 1532 (2011/08/03)
The development of a scalable chiral synthesis for the HCV NS5B inhibitor MK-3281 is being reported. Several alternative routes were explored and are being described. Georg Thieme Verlag Stuttgart ? New York.