(4R,5R)-cis-4-(ethoxycarbonyl)-5-(4-bromophenyl)-1-N-tosyl-2-imidazoline

Base Information

• Chemical Name: (4R,5R)-cis-4-(ethoxycarbonyl)-5-(4-bromophenyl)-1-N-tosyl-2-imidazoline
• CAS No.: 221000-82-4
• Molecular Formula: C₁₉H₁₉BrN₂O₄S
• Molecular Weight: 451.341
• Mol file: 221000-82-4.mol

Synonyms:(4R,5R)-cis-4-(ethoxycarbonyl)-5-(4-bromophenyl)-1-N-tosyl-2-imidazoline

Chemical Property of (4R,5R)-cis-4-(ethoxycarbonyl)-5-(4-bromophenyl)-1-N-tosyl-2-imidazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-cis-4-(ethoxycarbonyl)-5-(4-bromophenyl)-1-N-tosyl-2-imidazoline

There total 2 articles about (4R,5R)-cis-4-(ethoxycarbonyl)-5-(4-bromophenyl)-1-N-tosyl-2-imidazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

Ethyl isocyanoacetate (2999-46-4) + N-(4-bromobenzylidene)-4-methylbenzenesulfonamide (36176-90-6) → (4R,5R)-cis-4-(ethoxycarbonyl)-5-(4-bromophenyl)-1-N-tosyl-2-imidazoline (221000-82-4)

Guidance literature:

With dimethylsulfide gold(I) chloride; (R,S)-chiral ferrocenylphosphine; In dichloromethane; at 25 ℃; for 20h;

DOI:10.1016/S0957-4166(99)00052-X

Reference yield: 37.0%

Ethyl isocyanoacetate (2999-46-4) + N-(4-bromobenzylidene)-4-methylbenzenesulfonamide (36176-90-6) → (4R,5R)-cis-4-(ethoxycarbonyl)-5-(4-bromophenyl)-1-N-tosyl-2-imidazoline (221000-82-4) + (4S,5S)-cis-4-(ethoxycarbonyl)-5-(4-bromophenyl)-1-N-tosyl-2-imidazoline

Guidance literature:

dimethylsulfide gold(I) chloride; (Ph₂PC₅H₄)Fe(Ph₂PC₅H₃CHMeNMeCH₂CH₂N(CH₂)5); In dichloromethane; at 25 ℃; for 20h;

DOI:10.1021/jo980949s

Reference yield:

(4R,5R)-cis-4-(ethoxycarbonyl)-5-(4-bromophenyl)-1-N-tosyl-2-imidazoline (221000-82-4) → ethyl (2R,3R)-2-amino-3-(N-tosylamino)-3-(4-bromophenyl)propionate (228702-98-5)

Guidance literature:

With hydrogenchloride; In ethanol; at 60 ℃; for 4h; Yield given;

DOI:10.1016/S0957-4166(99)00052-X

upstream raw materials:

Ethyl isocyanoacetate

N-(4-bromobenzylidene)-4-methylbenzenesulfonamide

Downstream raw materials:

ethyl (2R,3R)-2-amino-3-(N-tosylamino)-3-(4-bromophenyl)propionate