benzocyclobutene-1-carboxaldehyde p-toluenesulphonylhydrazone

Base Information

• Chemical Name: benzocyclobutene-1-carboxaldehyde p-toluenesulphonylhydrazone
• CAS No.: 78926-34-8
• Molecular Formula: C₁₆H₁₆N₂O₂S
• Molecular Weight: 300.381
• Mol file: 78926-34-8.mol

Synonyms:benzocyclobutene-1-carboxaldehyde p-toluenesulphonylhydrazone

Chemical Property of benzocyclobutene-1-carboxaldehyde p-toluenesulphonylhydrazone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of benzocyclobutene-1-carboxaldehyde p-toluenesulphonylhydrazone

There total 2 articles about benzocyclobutene-1-carboxaldehyde p-toluenesulphonylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

benzocyclobutene-1-carboxaldehyde (78926-35-9) + toluene-4-sulfonic acid hydrazide (1576-35-8) → benzocyclobutene-1-carboxaldehyde p-toluenesulphonylhydrazone (78926-34-8)

Guidance literature:

In methanol; at 0 ℃; for 12h;

DOI:10.1016/S0040-4020(01)97701-4

Reference yield:

1-cyanobenzocyclobutane (6809-91-2) → benzocyclobutene-1-carboxaldehyde p-toluenesulphonylhydrazone (78926-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 34 percent / diisobutylaluminium hydride / benzene / 1.5 h

2: 74 percent / methanol / 12 h / 0 °C

With diisobutylaluminium hydride; In methanol; benzene;

DOI:10.1016/S0040-4020(01)97701-4

Reference yield:

benzocyclobutene-1-carboxaldehyde p-toluenesulphonylhydrazone (78926-34-8) → 1-methylenebenzocyclobutane (19164-64-8) + 1-indene (95-13-6)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, 15 min; 2.) THF, ice cooling, irradiation, 3 h;

DOI:10.1016/S0040-4020(01)97701-4

upstream raw materials:

benzocyclobutene-1-carboxaldehyde

toluene-4-sulfonic acid hydrazide

1-cyanobenzocyclobutane

Downstream raw materials:

1-methylenebenzocyclobutane

1-indene