5-(4-amino-2-methyl-3-oxobutan-2-yl)-2-fluorobenzonitrile hydrochloride

Base Information

Chemical Name:5-(4-amino-2-methyl-3-oxobutan-2-yl)-2-fluorobenzonitrile hydrochloride
CAS No.:1239964-13-6
Molecular Formula:C₁₂H₁₃FN₂O*ClH
Molecular Weight:256.707
Hs Code.:

Synonyms:5-(4-amino-2-methyl-3-oxobutan-2-yl)-2-fluorobenzonitrile hydrochloride

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Chemical Property of 5-(4-amino-2-methyl-3-oxobutan-2-yl)-2-fluorobenzonitrile hydrochloride

Chemical Property:

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Technology Process of 5-(4-amino-2-methyl-3-oxobutan-2-yl)-2-fluorobenzonitrile hydrochloride

There total 7 articles about 5-(4-amino-2-methyl-3-oxobutan-2-yl)-2-fluorobenzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1239964-12-5
5-(4-azido-2-methyl-3-oxobutan-2-yl)-2-fluorobenzonitrile

: 1239964-13-6
5-(4-amino-2-methyl-3-oxobutan-2-yl)-2-fluorobenzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; for 12h; under 760.051 Torr;

Reference yield:

: 1239964-09-0
3-(3-bromo-4-fluorophenyl)-3-methylbutan-2-one

: 1239964-13-6
5-(4-amino-2-methyl-3-oxobutan-2-yl)-2-fluorobenzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1-methyl-pyrrolidin-2-one / 24 h / 160 °C

2: tetra-n-butylammonium tribromide / dichloromethane; methanol / 48 h

3: sodium azide / N,N-dimethyl-formamide / 2 h / 0 °C

4: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol / 12 h / 760.05 Torr

With hydrogenchloride; sodium azide; tetra-n-butylammonium tribromide; hydrogen; platinum(IV) oxide; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1239964-06-7
2-(3-bromo-4-fluorophenyl)-2-methylpropanenitrile

: 1239964-13-6
5-(4-amino-2-methyl-3-oxobutan-2-yl)-2-fluorobenzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 2.5 h / -78 - 20 °C

1.2: 20 °C

2.1: diethyl ether; tetrahydrofuran / 3 h / 0 - 20 °C

3.1: pyridinium chlorochromate / dichloromethane / 24 h / 0 - 20 °C

4.1: 1-methyl-pyrrolidin-2-one / 24 h / 160 °C

5.1: tetra-n-butylammonium tribromide / dichloromethane; methanol / 48 h

6.1: sodium azide / N,N-dimethyl-formamide / 2 h / 0 °C

7.1: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol / 12 h / 760.05 Torr

With hydrogenchloride; sodium azide; tetra-n-butylammonium tribromide; hydrogen; diisobutylaluminium hydride; pyridinium chlorochromate; platinum(IV) oxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;