1-(3-(3-cyano-4-fluorophenyl)-3-methyl-2-oxobutyl)-3-(4-fluoro-3-methoxyphenyl)thiourea

Base Information

Chemical Name:1-(3-(3-cyano-4-fluorophenyl)-3-methyl-2-oxobutyl)-3-(4-fluoro-3-methoxyphenyl)thiourea
CAS No.:1239964-14-7
Molecular Formula:C₂₀H₁₉F₂N₃O₂S
Molecular Weight:403.453
Hs Code.:

Synonyms:1-(3-(3-cyano-4-fluorophenyl)-3-methyl-2-oxobutyl)-3-(4-fluoro-3-methoxyphenyl)thiourea

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Chemical Property of 1-(3-(3-cyano-4-fluorophenyl)-3-methyl-2-oxobutyl)-3-(4-fluoro-3-methoxyphenyl)thiourea

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Technology Process of 1-(3-(3-cyano-4-fluorophenyl)-3-methyl-2-oxobutyl)-3-(4-fluoro-3-methoxyphenyl)thiourea

There total 8 articles about 1-(3-(3-cyano-4-fluorophenyl)-3-methyl-2-oxobutyl)-3-(4-fluoro-3-methoxyphenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1000575-99-4
1-fluoro-4-isothiocyanato-2-methoxybenzene

: 1239964-13-6
5-(4-amino-2-methyl-3-oxobutan-2-yl)-2-fluorobenzonitrile hydrochloride

: 1239964-14-7
1-(3-(3-cyano-4-fluorophenyl)-3-methyl-2-oxobutyl)-3-(4-fluoro-3-methoxyphenyl)thiourea

Guidance literature:: With triethylamine; In dichloromethane; for 2h;

Reference yield:

: 1239964-09-0
3-(3-bromo-4-fluorophenyl)-3-methylbutan-2-one

: 1239964-14-7
1-(3-(3-cyano-4-fluorophenyl)-3-methyl-2-oxobutyl)-3-(4-fluoro-3-methoxyphenyl)thiourea

Guidance literature:: Multi-step reaction with 5 steps

1: 1-methyl-pyrrolidin-2-one / 24 h / 160 °C

2: tetra-n-butylammonium tribromide / dichloromethane; methanol / 48 h

3: sodium azide / N,N-dimethyl-formamide / 2 h / 0 °C

4: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol / 12 h / 760.05 Torr

5: triethylamine / dichloromethane / 2 h

With hydrogenchloride; sodium azide; tetra-n-butylammonium tribromide; hydrogen; triethylamine; platinum(IV) oxide; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1239964-06-7
2-(3-bromo-4-fluorophenyl)-2-methylpropanenitrile

: 1239964-14-7
1-(3-(3-cyano-4-fluorophenyl)-3-methyl-2-oxobutyl)-3-(4-fluoro-3-methoxyphenyl)thiourea

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 2.5 h / -78 - 20 °C

1.2: 20 °C

2.1: diethyl ether; tetrahydrofuran / 3 h / 0 - 20 °C

3.1: pyridinium chlorochromate / dichloromethane / 24 h / 0 - 20 °C

4.1: 1-methyl-pyrrolidin-2-one / 24 h / 160 °C

5.1: tetra-n-butylammonium tribromide / dichloromethane; methanol / 48 h

6.1: sodium azide / N,N-dimethyl-formamide / 2 h / 0 °C

7.1: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol / 12 h / 760.05 Torr

8.1: triethylamine / dichloromethane / 2 h

With hydrogenchloride; sodium azide; tetra-n-butylammonium tribromide; hydrogen; diisobutylaluminium hydride; triethylamine; pyridinium chlorochromate; platinum(IV) oxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;