3-(2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-4-oxoquinazolin-3(4H)-yl)-4-isopropoxybenzaldehyde

Base Information

Chemical Name:3-(2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-4-oxoquinazolin-3(4H)-yl)-4-isopropoxybenzaldehyde
CAS No.:1538593-70-2
Molecular Formula:C₃₁H₃₁ClN₄O₅
Molecular Weight:575.064
Hs Code.:

Synonyms:3-(2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-4-oxoquinazolin-3(4H)-yl)-4-isopropoxybenzaldehyde

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Chemical Property of 3-(2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-4-oxoquinazolin-3(4H)-yl)-4-isopropoxybenzaldehyde

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Technology Process of 3-(2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-4-oxoquinazolin-3(4H)-yl)-4-isopropoxybenzaldehyde

There total 4 articles about 3-(2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-4-oxoquinazolin-3(4H)-yl)-4-isopropoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1538593-69-9
2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-3-(2-isopropoxy-5-vinylphenyl)quinazolin-4(3H)-one

: 1538593-70-2
3-(2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-4-oxoquinazolin-3(4H)-yl)-4-isopropoxybenzaldehyde

Guidance literature:: 2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-3-(2-isopropoxy-5-vinylphenyl)quinazolin-4(3H)-one; With osmium(VIII) oxide; In 1,4-dioxane; water; for 0.166667h;

With sodium periodate; In 1,4-dioxane; water; at 25 ℃; for 24h;

Reference yield:

: 1538593-67-7
3-(5-bromo-2-isopropoxyphenyl)-2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one

: 1538593-70-2
3-(2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-4-oxoquinazolin-3(4H)-yl)-4-isopropoxybenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 0.17 h

1.2: 24 h / 70 °C

2.1: osmium(VIII) oxide / water; 1,4-dioxane / 0.17 h

2.2: 24 h / 25 °C

With bis-triphenylphosphine-palladium(II) chloride; osmium(VIII) oxide; In 1,4-dioxane; water;

Reference yield:

: 383869-57-6
4-bromo-2-nitro-1-(propan-2-yloxy)benzene

: 1538593-70-2
3-(2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-4-oxoquinazolin-3(4H)-yl)-4-isopropoxybenzaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride; tin(ll) chloride / tetrahydrofuran; water / 1.5 h / 50 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; phosphorus trichloride / 1,4-dioxane / 7 h / 70 °C / Inert atmosphere

3: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere

5: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 24 h / 70 °C

6: osmium(VIII) oxide; sodium periodate / water; 1,4-dioxane / 24 h / 20 °C

With hydrogenchloride; dmap; bis-triphenylphosphine-palladium(II) chloride; sodium periodate; osmium(VIII) oxide; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; phosphorus trichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmcl.2015.07.018