1538593-67-7

Upstream product

• 383869-57-6 4-bromo-2-nitro-1-(propan-2-yloxy)benzene 
• 4122-68-3 4-chlorophenyloxyacetyl chloride 

Downstream Products

• 1538593-69-9 2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-3-(2-isopropoxy-5-vinylphenyl)quinazolin-4(3H)-one 
• 1538593-70-2 3-(2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-4-oxoquinazolin-3(4H)-yl)-4-isopropoxybenzaldehyde 
• 1538593-71-3 2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-3-(2-isopropoxy-5-(piperazin-1-ylmethyl)phenyl)qiuinazolin-4(3H)-one 

Relevant academic research and scientific papers

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility

Introducing a reactive carbonyl to a scaffold that does not otherwise have an electrophilic functionality to create a reversible covalent inhibitor is a potentially useful strategy for enhancing compound potency. However, aldehydes are metabolically unsta