N-(2-{[2-(2,6-dimethylphenoxy)ethyl]amino}-5-propoxyphenyl)-2-piperidylacetamide

Base Information

Chemical Name:N-(2-{[2-(2,6-dimethylphenoxy)ethyl]amino}-5-propoxyphenyl)-2-piperidylacetamide
CAS No.:1446282-05-8
Molecular Formula:C₂₆H₃₇N₃O₃
Molecular Weight:439.598
Hs Code.:

Synonyms:N-(2-{[2-(2,6-dimethylphenoxy)ethyl]amino}-5-propoxyphenyl)-2-piperidylacetamide

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Chemical Property of N-(2-{[2-(2,6-dimethylphenoxy)ethyl]amino}-5-propoxyphenyl)-2-piperidylacetamide

Chemical Property:

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Technology Process of N-(2-{[2-(2,6-dimethylphenoxy)ethyl]amino}-5-propoxyphenyl)-2-piperidylacetamide

There total 7 articles about N-(2-{[2-(2,6-dimethylphenoxy)ethyl]amino}-5-propoxyphenyl)-2-piperidylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1446282-04-7
N-(2-amino-5-propoxyphenyl)-2-piperidylacetamide

: 37136-92-8
2-(2,6-Dimethyl-phenoxy)-1-bromo-ethane

: 1446282-05-8
N-(2-{[2-(2,6-dimethylphenoxy)ethyl]amino}-5-propoxyphenyl)-2-piperidylacetamide

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 120 ℃;

Reference yield:

: 28987-49-7
2-fluoro-1-nitro-4-propoxybenzene

: 1446282-05-8
N-(2-{[2-(2,6-dimethylphenoxy)ethyl]amino}-5-propoxyphenyl)-2-piperidylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide / water / 105 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: tetrahydrofuran / 55 °C / Cooling with ice

4: hydrogen; palladium 10% on activated carbon / ethanol / 3 h / 2947.82 Torr

5: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 120 °C

With ammonium hydroxide; palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 394-41-2
3-fluoro-4-nitrophenol

: 1446282-05-8
N-(2-{[2-(2,6-dimethylphenoxy)ethyl]amino}-5-propoxyphenyl)-2-piperidylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 100 °C

2: ammonium hydroxide / water / 105 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: tetrahydrofuran / 55 °C / Cooling with ice

5: hydrogen; palladium 10% on activated carbon / ethanol / 3 h / 2947.82 Torr

6: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 120 °C

With ammonium hydroxide; palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;