N-(5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxyphenyl)-2,4-difluorobenzenesulfonamide

Base Information

Chemical Name:N-(5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxyphenyl)-2,4-difluorobenzenesulfonamide
CAS No.:1449795-03-2
Molecular Formula:C₂₇H₂₀F₂N₄O₄S
Molecular Weight:534.543
Hs Code.:

Synonyms:N-(5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxyphenyl)-2,4-difluorobenzenesulfonamide

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Chemical Property of N-(5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxyphenyl)-2,4-difluorobenzenesulfonamide

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Technology Process of N-(5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxyphenyl)-2,4-difluorobenzenesulfonamide

There total 8 articles about N-(5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxyphenyl)-2,4-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1383992-15-1
2-amino-6-bromo-3-phenylquinazolin-4(3H)-one

: 1449795-04-3
2,4-difluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzenesulfonamide

: 1449795-03-2
N-(5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxyphenyl)-2,4-difluorobenzenesulfonamide

Guidance literature:: With caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 1.5h;
DOI:10.1021/jm400781h

Reference yield:

: 18009-07-9
6-bromo-3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

: 1449795-03-2
N-(5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxyphenyl)-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate; phosphorus pentachloride / 20 - 110 °C

2: N-ethyl-N,N-diisopropylamine / 4 h / 80 °C

3: trifluoroacetic acid / 48 h / Reflux

4: caesium carbonate / 1,4-dioxane; water / 1.5 h / 100 °C

With phosphorus pentachloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In 1,4-dioxane; water;
DOI:10.1021/jm400781h

Reference yield:

: 6358-77-6
5-bromo-2-methoxyaniline

: 1449795-03-2
N-(5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxyphenyl)-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 2 h / 20 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

3: caesium carbonate / 1,4-dioxane; water / 1.5 h / 100 °C

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; caesium carbonate; In 1,4-dioxane; water;
DOI:10.1021/jm400781h