6358-77-6Relevant articles and documents
Photocatalytic C-H Amination of Aromatics Overcoming Redox Potential Limitations
Ikarashi, Gun,Kano, Naokazu,Morofuji, Tatsuya
supporting information, p. 2822 - 2827 (2020/04/16)
We report the photocatalytic C-H amination of aromatics overcoming redox potential limitations. Radical cations of aromatic compounds are generated photocatalytically using Ru(phen)3(PF6)2, which has a reduction potential at a high oxidation state (Ered(RuIII/RuII) = +1.37 V vs SCE) lower than the oxidation potentials of aromatic substrates (Eox = +1.65 to +2.27 V vs SCE). The radical cations are trapped with pyridine to give N-arylpyridinium ions, which were converted to aromatic amines.
Direct and practical synthesis of primary anilines through iron-catalyzed C-H bond amination
Legnani, Luca,Cerai, Gabriele Prina,Morandi, Bill
, p. 8162 - 8165 (2018/05/22)
The direct C-H amination of arenes is an important strategy to streamline the discovery and preparation of functional molecules. Herein, we report an operationally simple arene C-H amination reaction that, in contrast to most literature precedent, affords directly the synthetically versatile primary aniline products without relying on protecting group manipulations. Inexpensive Fe(II)-sulfate serves as a convenient catalyst for the transformation. The reaction tolerates a wide scope of arenes, including structurally complex drugs. Importantly, the arene substrates are used as limiting reagents in the transformation. This operationally simple transformation should considerably accelerate the discovery of medicines and functional molecules.
7-HYDROXY-INDOLINYL ANTAGONISTS OF P2Y1 RECEPTOR
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Paragraph 00169, (2014/02/16)
The present invention provides compounds of Formula (I): Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor which may be used medicaments.
