(S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylate

Base Information

Chemical Name:(S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylate
CAS No.:141600-83-1
Molecular Formula:C₂₅H₃₀F₃NO₇
Molecular Weight:513.511
Hs Code.:

Synonyms:(S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylate

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Chemical Property of (S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylate

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Technology Process of (S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylate

There total 4 articles about (S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 138279-18-2
(S)-(+)-4-(2-trifluoromethylphenyl)-1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid

: 141600-83-1
(S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylate

Guidance literature:: In diethyl ether; dichloromethane; at 0 ℃; for 1h;
DOI:10.1248/cpb.45.863

Reference yield:

: 18997-19-8
Chloromethyl pivalate

: 141600-83-1
(S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 18 h

2: 83 percent / lipase AH, H₂O / diisopropyl ether / 7 h / Ambient temperature

3: 97 percent / diethyl ether; CH₂Cl₂ / 1 h / 0 °C

With lipase AH; water; sodium hydride; In diethyl ether; dichloromethane; di-isopropyl ether;
DOI:10.1248/cpb.45.863

Reference yield:

: 141600-82-0
1-Methoxymethyl-2,6-dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid

: 141600-83-1
(S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 18 h

2: 83 percent / lipase AH, H₂O / diisopropyl ether / 7 h / Ambient temperature

3: 97 percent / diethyl ether; CH₂Cl₂ / 1 h / 0 °C

With lipase AH; water; sodium hydride; In diethyl ether; dichloromethane; di-isopropyl ether;
DOI:10.1248/cpb.45.863