3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-[2-(trifluoromethyl)phenyl] -, mono[(2,2-dimethyl-1-oxopropoxy)methyl] ester, (S)-

Base Information

Chemical Name:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-[2-(trifluoromethyl)phenyl] -, mono[(2,2-dimethyl-1-oxopropoxy)methyl] ester, (S)-
CAS No.:138279-18-2
Molecular Formula:C24H28F3NO7
Molecular Weight:499.484
Hs Code.:

3,5-Pyridinedicarboxylic acid,
1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-[2-(trifluoromethyl)phenyl]
-, mono[(2,2-dimethyl-1-oxopropoxy)methyl] ester, (S)-

Synonyms:

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Chemical Property of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-[2-(trifluoromethyl)phenyl] -, mono[(2,2-dimethyl-1-oxopropoxy)methyl] ester, (S)-

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Technology Process of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-[2-(trifluoromethyl)phenyl] -, mono[(2,2-dimethyl-1-oxopropoxy)methyl] ester, (S)-

There total 6 articles about 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-[2-(trifluoromethyl)phenyl] -, mono[(2,2-dimethyl-1-oxopropoxy)methyl] ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 138279-14-8
bis(pivaloyloxymethyl) 4-(2-trifluoromethylphenyl)-1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-3,5-pyridinedicarboxylate

: 138279-18-2
1-Methoxymethyl-2,6-dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid mono-(2,2-dimethyl-propionyloxymethyl) ester

Guidance literature:: In di-isopropyl ether; water; at 25 ℃; for 7h; lipase B;
DOI:10.1016/S0040-4039(00)93560-3

Reference yield: 83.0%

: 138279-14-8
bis(pivaloyloxymethyl) 4-(2-trifluoromethylphenyl)-1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-3,5-pyridinedicarboxylate

: 138279-18-2
(S)-(+)-4-(2-trifluoromethylphenyl)-1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid

Guidance literature:: With lipase AH; water; In di-isopropyl ether; for 7h; Ambient temperature;
DOI:10.1248/cpb.45.863

Reference yield:

: 18997-19-8
Chloromethyl pivalate

: 138279-18-2
1-Methoxymethyl-2,6-dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid mono-(2,2-dimethyl-propionyloxymethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / dimethylformamide

2: 83 percent / diisopropyl ether; H₂O / 7 h / 25 °C / lipase B

With sodium hydride; In di-isopropyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)93560-3