Technology Process of (S)-5-benzyl-3-(p-tolyl)imidazolidine-2,4-dione
There total 2 articles about (S)-5-benzyl-3-(p-tolyl)imidazolidine-2,4-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S)-2-amino-N-(4-methylphenyl)-3-phenylpropanamide;
With
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; acetic acid;
at 80 ℃;
for 0.0833333h;
Schlenk technique;
Inert atmosphere;
Sealed tube;
Green chemistry;
carbon monoxide;
at 80 ℃;
for 2h;
under 760.051 Torr;
Schlenk technique;
Inert atmosphere;
Sealed tube;
Green chemistry;
DOI:10.1039/d1cc04154a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper(l) iodide; potassium carbonate / toluene / 48 h / 110 °C
2.1: acetic acid; palladium diacetate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / 0.08 h / 80 °C / Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry
2.2: 2 h / 80 °C / 760.05 Torr / Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry
With
copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; potassium carbonate; acetic acid;
In
toluene;
DOI:10.1039/d1cc04154a
