2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)-acetonitrile

Base Information

Chemical Name:2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)-acetonitrile
CAS No.:1158805-04-9
Molecular Formula:C₁₉H₂₅N₅O
Molecular Weight:339.44
Hs Code.:

Synonyms:2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)-acetonitrile

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Chemical Property of 2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)-acetonitrile

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Technology Process of 2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)-acetonitrile

There total 9 articles about 2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1158805-03-8
2-(3-((2-amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)acetonitrile

: 109-73-9,85404-21-3
N-butylamine

: 1158805-04-9
2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)-acetonitrile

Guidance literature:: In butan-1-ol; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

: 773837-37-9
sodium cyanide

: N⁴-butyl-5-(5-(chloromethyl)-2-methoxybenzyl)-6-methylpyrimidine-2,4-diamine

: 1158805-04-9
2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)-acetonitrile

Guidance literature:: In dimethyl sulfoxide; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: methyl 3-(bromomethyl)-4-methoxy-benzoate

: 1158805-04-9
2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)-acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 70 °C

2.1: methanol / 16 h / 65 °C

3.1: trichlorophosphate / 15 h / 100 °C

4.1: 1-methyl-pyrrolidin-2-one / 150 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

6.1: thionyl chloride / dichloromethane / 1 h / 20 °C / Inert atmosphere

7.1: N,N-dimethyl-formamide; dimethyl sulfoxide / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sodium hydride; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;