1-(4-aminosulfonylphenyl)-3-ethoxycarbonyl-5-(3-phenanthryl)-1H-pyrazole

Base Information

• Chemical Name: 1-(4-aminosulfonylphenyl)-3-ethoxycarbonyl-5-(3-phenanthryl)-1H-pyrazole
• CAS No.: 1427216-84-9
• Molecular Formula: C₂₆H₂₁N₃O₄S
• Molecular Weight: 471.536

Synonyms:1-(4-aminosulfonylphenyl)-3-ethoxycarbonyl-5-(3-phenanthryl)-1H-pyrazole

Chemical Property of 1-(4-aminosulfonylphenyl)-3-ethoxycarbonyl-5-(3-phenanthryl)-1H-pyrazole

Chemical Property:

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Technology Process of 1-(4-aminosulfonylphenyl)-3-ethoxycarbonyl-5-(3-phenanthryl)-1H-pyrazole

There total 2 articles about 1-(4-aminosulfonylphenyl)-3-ethoxycarbonyl-5-(3-phenanthryl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2-hydroxy-4-oxo-4-(2-phenanthryl)but-2-enoic acid ethyl ester (1314023-78-3) + 4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0) → 1-(4-aminosulfonylphenyl)-3-ethoxycarbonyl-5-(3-phenanthryl)-1H-pyrazole (1427216-84-9)

Guidance literature:

In ethanol; for 4h; Reflux;

DOI:10.1016/j.bmc.2012.10.029

Reference yield:

2-acetylphenanthrene (5960-69-0) → 1-(4-aminosulfonylphenyl)-3-ethoxycarbonyl-5-(3-phenanthryl)-1H-pyrazole (1427216-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethanolate / ethanol / 3 h / 50 °C / Reflux

2: ethanol / 4 h / Reflux

With sodium ethanolate; In ethanol; 1: |Claisen Condensation;

DOI:10.1016/j.bmc.2012.10.029

Reference yield: 85.0%

1-(4-aminosulfonylphenyl)-3-ethoxycarbonyl-5-(3-phenanthryl)-1H-pyrazole (1427216-84-9) → C24H19N3O3S (1427216-97-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2012.10.029

upstream raw materials:

2-hydroxy-4-oxo-4-(2-phenanthryl)but-2-enoic acid ethyl ester

4-hydrazinobenzene-1-sulfonamide hydrochloride

2-acetylphenanthrene

Downstream raw materials:

C₂₄H₁₉N₃O₃S

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