1-(4-Aminobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(4-Aminobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:180623-53-4
Molecular Formula:C₂₀H₂₁F₃N₂O₃
Molecular Weight:394.394
Hs Code.:

Synonyms:1-(4-Aminobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 1-(4-Aminobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 1-(4-Aminobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

There total 6 articles about 1-(4-Aminobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 180623-50-1
6,7-Dimethoxy-1-(4-nitrobenzyl)-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

: 180623-53-4
1-(4-Aminobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2h; under 3102.9 Torr;
DOI:10.1021/jm960208o

Reference yield:

: 10268-26-5
1,2,3,4-tetrahydro-6,7-dimethoxy-1-[(4-nitrophenyl)methyl]isoquinoline

: 180623-53-4
1-(4-Aminobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / tetrahydrofuran / Ambient temperature

2: 87 percent / H₂ / 5percent Pd/C / ethyl acetate / 2 h / 3102.9 Torr

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm960208o

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 180623-53-4
1-(4-Aminobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / toluene / 72 h / Heating

2: POCl₃ / acetonitrile / 4 h / Heating

3: NaBH₄ / methanol / Ambient temperature

4: 50 percent / tetrahydrofuran / Ambient temperature

5: 87 percent / H₂ / 5percent Pd/C / ethyl acetate / 2 h / 3102.9 Torr

With sodium tetrahydroborate; hydrogen; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/jm960208o